|6,7-二甲氧基-N-(3-苯氧基苯基)喹啉-4-胺盐酸盐|CsnPharm

CAS No.: 179246-08-3

Synonyms: UNC10225170 HCl;UNC10225170 hydrochloride

GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein.

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400-920-2911

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描述The KRAS gene is an oncogene that encodes a GTPase transductor protein, K-Ras. The mutant KRAS regulates Myc, a transcription factor in MAPK/ERK signaling pathway, via ERK1/2-dependent and independent mechanisms in pancreatic ductal adenocarcinoma. MEK5 is a key component in MAPK pathway that phosphorylates and activates non-classical MAPK ERK5. GW284543 HCl is the hydrochloride form of GW284543. GW284543, also known as UNC10225170, is a 4-anilinoquin(az)oline chemotype that selectively inhibits MEK5. Treatment of MIA PaCa-2 cells with GW284543 (10 and 20 μM) for 6 h decreased the expression of endogenous Myc protein in a concentration-dependent manner. The GW284543 treatment (10 and 20 μM) also dose-dependently inhibited MEK5 in MIA PaCa-2 cells, as indicated by the reduction in phosphorylated ERK5^[1].
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CAS号	179246-08-3	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C23H21ClN2O3	运输	蓝冰
分子量	408.88	别名	UNC10225170 HCl;UNC10225170 hydrochloride

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