|1-甲基-6-氧代吡啶-3-甲酰胺|CsnPharm

CAS No.: 701-44-0

Nudifloramide/1-甲基-6-氧代吡啶-3-甲酰胺 Catalog No. CSN27556

Synonyms: 2PY;N-methyl-2-Pyridone-5-Carboxamide;地氟酰胺

Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro.

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技术信息

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描述Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme, highly involved in a variety of extremely important physiologic events, including regulation of gene expression, cellular differentiation, apoptosis, DNA replication, and DNA repair. Moreover, PARP-1 plays an important role in nicotinamide-adenine dinucleotide (NAD) degradation. As one of the end products of NAD degradation, nudifloramide significantly inhibited PARP-1 activity in vitro with an IC₅₀ value of 8 μM (1.22 mg/L). This IC₅₀ value fell within the range of blood nudifloramide concentrations observed in dialysis patients. The nudifloramide concentrations were many times elevated in nondialyzed chronic renal failure (CRF) patients when compared with controls. The direct correlations were found between serum nudifloramide concentrations and serum creatinine concentration, and negative correlations between serum nudifloramide concentrations and creatinine clearance. The concentration of nudifloramide decreased considerably after hemodialysis (HD) session and permanently declined after kidney transplantation suggesting that it could be a novel uremic toxin^[2].
参考文献

[1] Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May;(84):S19-21.
[2] Lenglet A, Liabeuf S, Bodeau S, Louvet L, Mary A, Boullier A, Lemaire-Hurtel AS, Jonet A, Sonnet P, Kamel S, Massy ZA. N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin. Toxins (Basel). 2016 Nov 15;8(11):339.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.5725 mL
- 32.8623 mL
- 65.7246 mL
- 5 mM
- 1.3145 mL
- 6.5725 mL
- 13.1449 mL
- 10 mM
- 0.6572 mL
- 3.2862 mL
- 6.5725 mL

技术信息

CAS号

701-44-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H8N2O2

运输

蓝冰

分子量

152.15

别名

2PY;N-methyl-2-Pyridone-5-Carboxamide;地氟酰胺

溶解度

DMSO	60.0 mg/mL (394.3 mM) warming

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Nudifloramide/1-甲基-6-氧代吡啶-3-甲酰胺 Catalog No. CSN27556

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