CAS No.: 2316837-10-0
ARD-69 Catalog No. CSN28523
ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manner. ARD-69 achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, respectively. ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression.
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技术信息
| CAS号 | 2316837-10-0 | 储存条件 |
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| 分子式 | C62H74ClFN8O7S | 运输 | 蓝冰 | |
| 分子量 | 1129.82 | 别名 |
