CAS No.: 73819-26-8
Furamidine Catalog No. CSN26668
Synonyms: DB75;NSC 305831;BRN 1435532
Furamidine, also known as DB75, is a cell-permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) that is selective for PRMT1. Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furthermore, cellular studies revealed that 1 is cell membrane permeable and effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.
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技术信息
| CAS号 | 73819-26-8 | 储存条件 |
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| 分子式 | C18H16N4O | 运输 | 蓝冰 | |
| 分子量 | 304.35 | 别名 | DB75;NSC 305831;BRN 1435532 |
