CAS No.: 1629013-22-4
GSK3368715 Catalog No. CSN26479
Synonyms: EPZ019997
GSK3368715, aslo known as EPZ019997, is a potent, reversible type I PRMT inhibitor with anti-tumor effects in human cancer models. Inhibition of PRMT5, the predominant type II PRMT, produces synergistic cancer cell growth inhibition when combined with GSK3368715. Interestingly, deletion of the methylthioadenosine phosphorylase gene (MTAP) results in accumulation of the metabolite 2-methylthioadenosine, an endogenous inhibitor of PRMT5, and correlates with sensitivity to GSK3368715 in cell lines.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1629013-22-4 | 储存条件 |
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| 分子式 | C20H38N4O2 | 运输 | 蓝冰 | |
| 分子量 | 366.54 | 别名 | EPZ019997 |
