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CAS No.: 1155877-97-6

D 159687 is selective inhibitor of PDE4B and PDE4D with brain permeability.

规格	价格	促销价格	库存	数量

400-920-2911

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描述The cyclic AMP (cAMP)-specific phosphodiesterase 4 (PDE4) enzyme family is a critical component of signaling pathways involving multiple neurological diseases. This enzyme family consists of 4 subtypes (PDE4A-D) that are independently coded by different genes. Inhibition of PDE4 has been proposed as a potential treatment for a series of neuropsychological conditions such as depression, anxiety and memory loss. D159687 is a selective PDE4D inhibitor. D159687 increased cAMP accumulation in HT-22 cells in a dose-dependent manner. For D159687, 0.1 and 1 μM concentrations significantly increased the cAMP accumulation (F (3, 20) = 6.165, P = 0.0061). D159687 induced a transient increase in CREB phosphorylation which peaked at 6 hrs after treatment (F (3, 20) = 3.731, P = 0.0425). CREB phosphorylation was optimal at 1 μM (F (3, 20) = 4.194, P = 0.0302). The possible memory enhancing effects of D159687 were evaluated in mice after a single acute dose given immediately after the T1 training session. D159687 at 3 mg/kg significantly increased the discrimination ratio in T2 of the NOR test (F (3, 40) = 7.516, P = 0.0004)^[1].
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技术信息

CAS号

1155877-97-6

储存条件

分子式

C21H19ClN2O2

运输

蓝冰

分子量

366.84

别名

溶解度

DMSO	180.0 mg/mL (490.7 mM)
Water	insoluble

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