|(S)-5,7-二羟基-2-(3-羟基-4-甲氧基苯基)苯并二氢吡喃-4-酮|CsnPharm

CAS No.: 520-33-2

橙皮素 Catalog No. CSN16383

Synonyms: (–)-Hesperetin;(S)-Hesperetin;NSC 57654

Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay.

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技术信息

生物活性

描述Hesperetin is an effective antioxidant and anti-inflammatory agent. Hesperetin conferred neuroprotection by regulating the TLR4/NF-κB (Toll-like receptor-4) signaling pathway against the detrimental effects of LPS(lipopolysaccharide) ^[3]. Hesperetin (HET) and naringenin (NGR) are flavanones found in citrus (oranges and grapefruit) and Aurantii Fructus Immaturus. HET and NGR displayed broad-spectrum inhibition against human UGTs. HET exhibited strong inhibitory effects on UGT1A1, 1A3 and 1A9 (both IC50 and Ki values lower than 10 µM) ^[4]. Hesperetin interacts with different types of proteins involving hydrogen bonds, pi-pi effects, pi-cation bonding and pi-sigma interactions with varying binding energies. Hesperetin exhibits drug-like properties which projects its potential as a therapeutic option for CHIKV infection^[5]. Preadministration of Hesperetin (40 mg/kg b.w., oral) significantly attenuated the Cd-induced (cadmium) oxidative stress and mitochondrial dysfunction, restored the antioxidant and membrane-bound enzyme activities and decreased apoptosis in the brain of rats^[6]. Hesperetin (200 mg/kg) attenuates Con A-induced hepatocyte apoptosis and hepatic Nos2 (iNOS) expression in mice. Hesperetin blocked bile acid-induced apoptosis and cytokine-induced inflammation in rat hepatocytes^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03032861	Intestinal Diseases	Not Applicable	Completed	-	Brazil ... more >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Araraquara, Sao Paulo, Brazil, 14800-903 Collapse <<
NCT03527277	Cardiovascular Risk Factor ... more >> Type2 Diabetes Mellitus Insulin Sensitivity Metabolic Syndrome Collapse <<	Not Applicable	Recruiting	March 31, 2023	United States, California ... more >> University of California, Davis Recruiting Davis, California, United States, 95616 Contact: Kimber Stanhope, Ph.D. 530-752-3720 klstanhope@ucdavis.edu Contact: Vivien Lee, B.S. 530-752-2714 vilee@ucdavis.edu Collapse <<
NCT02380144	Healthy	Not Applicable	Unknown	July 2017	Germany ... more >> Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3082 mL
- 16.5410 mL
- 33.0820 mL
- 5 mM
- 0.6616 mL
- 3.3082 mL
- 6.6164 mL
- 10 mM
- 0.3308 mL
- 1.6541 mL
- 3.3082 mL

技术信息

CAS号

520-33-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14O6

运输

蓝冰

分子量

302.28

别名

(–)-Hesperetin;(S)-Hesperetin;NSC 57654;(–)-3',5,7-Trihydroxy-4'-methoxyflavanone;Hesperitin;Hesperin;YSO2;Prestwick_908;橙皮素

溶解度

DMSO	59.0 mg/mL (195.2 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03032861	Intestinal Diseases	Not Applicable	Completed	-	Brazil ... more >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Araraquara, Sao Paulo, Brazil, 14800-903 Collapse <<
NCT03527277	Cardiovascular Risk Factor ... more >> Type2 Diabetes Mellitus Insulin Sensitivity Metabolic Syndrome Collapse <<	Not Applicable	Recruiting	March 31, 2023	United States, California ... more >> University of California, Davis Recruiting Davis, California, United States, 95616 Contact: Kimber Stanhope, Ph.D. 530-752-3720 klstanhope@ucdavis.edu Contact: Vivien Lee, B.S. 530-752-2714 vilee@ucdavis.edu Collapse <<
NCT02380144	Healthy	Not Applicable	Unknown	July 2017	Germany ... more >> Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT02251678	Plaque Psoriasis	Phase 1	Completed	-	United States, Illinois ... more >> NMFF Dermatology Clinic Chicago, Illinois, United States, 60611 NM Lake Forest Hospital/ Women's Center Lake Forest, Illinois, United States, 60045 United States, New Jersey TKL Research Fair Lawn, New Jersey, United States, 07410 United States, Ohio University Hospitals Case Medical Center / Dept of Dermatology Cleveland, Ohio, United States, 44106 Collapse <<
NCT00539916	Cardiovascular Disease Risk Fa... more >>ctors Collapse <<	Not Applicable	Completed	-	France ... more >> Hopital Saint André - Service de Médecine Interne - Pathologie Vasculaire Bordeaux, France, 33075 Collapse <<
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... more >> University of Glasgow School of Medicine Glasgow, United Kingdom Collapse <<
NCT02095873	Glucose Intolerance ... more >> Aortic Stiffness Vasodilation Collapse <<	Phase 1 Phase 2	Completed	-	United Kingdom ... more >> University Hospitals Coventry & Warwickshire NHS Trust (UHCW) Coventry, Warwickshire, United Kingdom, CV22DX Collapse <<
NCT02095873	-	-	Completed	-	-

橙皮素 Catalog No. CSN16383

靶点选择性

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