|1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮|CsnPharm

CAS No.: 41443-28-1

Synonyms: 1H-ODQ;H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

ODQ is a selective and irreversible inhibitor of nitric oxide-sensitive guanylyl cyclase.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述Soluble guanylyl cyclase (sGC) is the principal enzyme in mediating the biological actions of nitric oxide. On activation, sGC converts guanosine triphosphate to guanosine 3',5'-cyclic monophosphate (cGMP), which mediates diverse physiological processes including vasodilation, platelet aggregation, and myocardial functions predominantly by acting on cGMP-dependent protein kinases^[1].Impaired NO-sGC-cGMP signaling could lead to osteoblast apoptosis by mechanisms involving the oxidative-stress-induced shift of the redox state of the reduced heme to oxidized sGC, leading to diminished heme binding to the enzyme and rendering the sGC unresponsive to NO. Targeting oxidized sGC to enhance cGMP production could restore proliferation and differentiation of osteoblasts into osteocytes^[2]. ODQ is a potent and selective sGC inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells. At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM^[3]. ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat^[4].
参考文献

实验方案

技术信息

CAS号	41443-28-1	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H5N3O2	运输	蓝冰
分子量	187.15	别名	1H-ODQ;H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户