|4-(4-(3-(4-氯-3-(三氟甲基)苯基)脲基)苯氧基)-N-(甲基-d3)吡啶-2-甲酰胺|CsnPharm

CAS No.: 1130115-44-4

Sorafenib-d3 Catalog No. CSN27589

Synonyms: Bay 43-9006-d3;Donafenib;Sorafenib (D3)

Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively.

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描述Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively.^[2]. FGL1 expression was higher in HepG2, Huh7, and Hep3B cells than in SNU387, SNU449, and SNU475 cells; high FGL1-expressing HCC cells showed a lower IC50 and higher sensitivity to sorafenib. In Huh7 and Hep3B cells, FGL1 knockdown significantly increased colony formation by 61% (p = 0.0013) and 99% (p = 0.0002), respectively, compared to that in controls and abolished sorafenib-induced suppression of colony formation, possibly by modulating ERK and autophagy signals^[3].Sorafenib treatment induced the compensatory activation of the AKT pathway and autocrine VEGF in hepatoma cells, which could be reversed by celastrol. Furthermore, celastrol enhanced the growth inhibition and apoptosis induction of cancer cells by sorafenib both in vitro and in vivo and reduced the dosage of sorafenib needed^[4].Changes in expression and genetic mutations of OATP1B1 significantly affected the uptake of sorafenib in HepG2 and LO2 transgenic cells, and the uptake of sorafenib was higher in HepG2 than LO2^[5].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1375 mL
- 10.6873 mL
- 21.3747 mL
- 5 mM
- 0.4275 mL
- 2.1375 mL
- 4.2749 mL
- 10 mM
- 0.2137 mL
- 1.0687 mL
- 2.1375 mL

技术信息

CAS号	1130115-44-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H16ClF3N4O3	运输	蓝冰
分子量	467.84	别名	Bay 43-9006-d3;Donafenib;Sorafenib (D3);Bay 43-9006 (D3);CM-4307

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