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CAS No.: 145-63-1
Synonyms: Germanin;苏拉明
Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM).
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT02347332 | Recurrent or Metastatic Head a... more >>nd Neck Carcinoma Collapse << | Phase 3 | Active, not recruiting | June 2018 | - |
NCT02871284 | Exercise Chem... more >>otherapy-induced Polyneuropathy Collapse << | Phase 2 Phase 3 | Recruiting | December 2019 | Germany ... more >> National Center for Tumor Diseases Recruiting Heidelberg, Germany, 69120 Contact: Joachim Wiskemann, Dr. joachim.wiskemann@nct-heidelberg.de Contact: Jana Müller jana.mueller@nct-heidelberg.de Collapse << |
NCT00001230 | - | - | Recruiting | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-441-1222 ext TTY8864111010 prpl@cc.nih.gov Collapse << |
实验方案
技术信息
CAS号 | 145-63-1 | 储存条件 |
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分子式 | C51H40N6O23S6 | 运输 | 蓝冰 | |
分子量 | 1297.28 | 别名 | Germanin;苏拉明 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02347332 | Recurrent or Metastatic Head a... more >>nd Neck Carcinoma Collapse << | Phase 3 | Active, not recruiting | June 2018 | - |
NCT02871284 | Exercise Chem... more >>otherapy-induced Polyneuropathy Collapse << | Phase 2 Phase 3 | Recruiting | December 2019 | Germany ... more >> National Center for Tumor Diseases Recruiting Heidelberg, Germany, 69120 Contact: Joachim Wiskemann, Dr. joachim.wiskemann@nct-heidelberg.de Contact: Jana Müller jana.mueller@nct-heidelberg.de Collapse << |
NCT00001230 | - | - | Recruiting | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-441-1222 ext TTY8864111010 prpl@cc.nih.gov Collapse << |
NCT00002881 | Prostate Cancer | Phase 3 | Completed | - | United States, District of Col... more >>umbia Walter Reed Army Medical Center Washington, District of Columbia, United States, 20307-5000 Collapse << |
NCT00003038 | Adrenocortical Carcinoma ... more >> Breast Cancer Colorectal Cancer Prostate Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 Collapse << |
NCT00002639 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> Department of Neurosurgery - Emory Atlanta, Georgia, United States, 30322 Collapse << |
NCT00006476 | Bladder Cancer | Phase 1 | Completed | - | United Kingdom ... more >> Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Collapse << |
NCT00001266 | Prostatic Neoplasm | Phase 2 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00004073 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 2 | Completed | - | United States, Alabama ... more >> University of Alabama Comprehensive Cancer Center Birmingham, Alabama, United States, 35294 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, Georgia Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins Oncology Center Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Comprehensive Cancer Center of Wake Forest University Baptist Medical Center Winston-Salem, North Carolina, United States, 27157-1082 United States, Pennsylvania University of Pennsylvania Cancer Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78284-7811 Collapse << |
NCT00002652 | Multiple Myeloma and Plasma Ce... more >>ll Neoplasm Collapse << | Phase 2 | Completed | - | United States, Arkansas ... more >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Collapse << |
NCT00001381 | Bladder Neoplasms ... more >> Carcinoma, Transitional Cell Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00002723 | Prostate Cancer | Phase 3 | Completed | - | - |
NCT00006929 | Recurrent Non-small Cell Lung ... more >>Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer Collapse << | Phase 2 | Completed | - | United States, Ohio ... more >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
NCT00002921 | Adrenocortical Carcinoma | Phase 2 | Terminated(Permanently Closed ... more >>Due to Lack of Accrual) Collapse << | - | - |
NCT00054028 | Recurrent Breast Cancer ... more >> Stage IIIB Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 Phase 2 | Completed | - | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
NCT00066768 | Recurrent Non-small Cell Lung ... more >>Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer Collapse << | Phase 1 | Completed | - | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
NCT00054028 | - | - | Completed | - | - |
NCT00083109 | Recurrent Renal Cell Carcinoma... more >> Stage IV Renal Cell Cancer Collapse << | Phase 1 Phase 2 | Completed | - | United States, Ohio ... more >> Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Collapse << |
NCT01038752 | Non-small Cell Lung Cancer | Phase 2 | Terminated | - | United States, Illinois ... more >> John H Stroger Jr Hospital of Cook County Chicago, Illinois, United States, 60612 United States, Virginia Virginia Commonwealth University Massey Cancer Center Richmond, Virginia, United States, 23298 Collapse << |
NCT01671332 | Carcinoma, Non Small Cell Lung | Phase 2 | Unknown | December 2016 | United States, Wisconsin ... more >> University of Wisconsin Carbone Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Medical College of Wisconsin Milwaukee, Wisconsin, United States Collapse << |
NCT02508259 | Autism Spectrum Disorders | Phase 1 Phase 2 | Completed | - | United States, California ... more >> University of California, San Diego School of Medicine La Jolla, California, United States, 92093 Collapse << |
NCT01038752 | - | - | Terminated | - | - |
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