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CAS No.: 75629-57-1

Oncrasin-1 Catalog No. CSN12470

Synonyms: Oncrasin-1

Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

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技术信息

生物活性

描述The oncogenic gene K-Ras mutations are frequently found in various cancers and are associated with resistance to treatment or poor prognosis. Oncrasin-1 is a potent and effective anticancer inhibitor against various lung cancer cells with K-Ras mutations at low or submicromolar concentrations. Oncrasin-1 induced dose-dependent cytotoxicity in T29Kt1 cells with an IC₅₀ of 4.81 μM. Oncrasin-1 effectively killed K-Ras–mutant H460, H2122, H2887, and A549 cells with an IC₅₀ of ≤3 μM. Oncrasin-1 (10 μM) effectively induced cell killing in T29Kt1 and H460 cells. Additionally, treatment of H460 cells with 1 μM oncrasin-1 effectively activated caspases 3 and 8. Oncrasin-1 (100 mg/kg/injection daily for 10 days) suppressed tumor growth by 75.4% in mice. Treatment with oncrasin-1 also prolonged survival: the mean survival times for mice treated with solvent and oncrasin-1 were 24 and 32, respectively, demonstrating that Oncrasin-1 might be useful for the treatment of cancers with K-Ras mutations^[1].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7075 mL
- 18.5374 mL
- 37.0747 mL
- 5 mM
- 0.7415 mL
- 3.7075 mL
- 7.4149 mL
- 10 mM
- 0.3707 mL
- 1.8537 mL
- 3.7075 mL

技术信息

CAS号

75629-57-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12ClNO

运输

蓝冰

分子量

269.73

别名

Oncrasin-1

溶解度

DMSO	43.0 mg/mL (159.4 mM)

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