|2,3-双(2-羟基乙硫基)-1,4-萘二酮|CsnPharm

CAS No.: 93718-83-3

NSC 95397 Catalog No. CSN25261

Synonyms: Cdc25 Inhibitor IV;PTP Inhibitor XXIX

NSC 95397 is irreversible Cdc25 dual specificity phosphatase inhibitor with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C) with IC50s of 22.3 nM (human Cdc25A), of 56.9 nM (human Cdc25C), of 125 nM (Cdc25B)^[1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway. Treatment with NSC 95397 at 0, 10 µM, and 20 µM for 24 hour decreased the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner^[2]. NSC95397 also dose-dependently suppressed the production of nitric oxide (NO), tumor necrosis factor (TNF)-α, and prostaglandin (PG)E2, and diminished the mRNA expression of inflammatory genes such as inducible NO synthase (iNOS), cyclooxygenase (COX)-2, interferon (IFN)-β, and TNF-α in peritoneal macrophages and RAW264.7 cells that were stimulated by LPS and pam3CSK^[3]. In addition, NSC-95397 triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect in part requiring entry of Ca2+ and activation of staurosporine sensitive kinase(s)^[4].
参考文献

[1] Lazo JS, Nemoto K, Pestell KE, Cooley K, Southwick EC, Mitchell DA, Furey W, Gussio R, Zaharevitz DW, Joo B, Wipf P. Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol Pharmacol. 2002 Apr;61(4):720-8.
[2] Dubey NK, Peng BY, Lin CM, Wang PD, Wang JR, Chan CH, Wei HJ, Deng WP. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. Int J Mol Sci. 2018 May 31;19(6):1625.
[3] Yang Y, Yang WS, Yu T, Yi YS, Park JG, Jeong D, Kim JH, Oh JS, Yoon K, Kim JH, Cho JY. Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases. Biochem Pharmacol. 2014 Mar 15;88(2):201-15.
[4] Jemaà M, Mischitelli M, Fezai M, Almasry M, Faggio C, Lang F. Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397. Cell Physiol Biochem. 2016;40(3-4):597-607.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2218 mL
- 16.1088 mL
- 32.2177 mL
- 5 mM
- 0.6444 mL
- 3.2218 mL
- 6.4435 mL
- 10 mM
- 0.3222 mL
- 1.6109 mL
- 3.2218 mL

技术信息

CAS号	93718-83-3	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H14O4S2	运输	蓝冰
分子量	310.39	别名	Cdc25 Inhibitor IV;PTP Inhibitor XXIX

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NSC 95397 Catalog No. CSN25261

靶点选择性

请登录您的专属账户

确认信息