CAS No.: 1070790-89-4
Fadraciclib Catalog No. CSN26613
Synonyms: CYC065
Fadraciclib, also known as CYC065, is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities. CYC065 selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow.
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技术信息
| CAS号 | 1070790-89-4 | 储存条件 |
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| 分子式 | C21H31N7O | 运输 | 蓝冰 | |
| 分子量 | 397.52 | 别名 | CYC065 |
