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CAS No.: 58-60-6

Puromycin aminonucleoside/氨基核苷嘌呤霉素 Catalog No. CSN11798

Synonyms: NSC 3056;Puromycin Aminonucleoside;PANS

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin and it is a puromycin analog which does not inhibit protein synthesis but induces apoptosis.. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase.

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生物活性

描述Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models^[3]. Puromycin aminonucleoside (30 μg/mL) markedly increases p53 protein levels in podocytes. Puromycin aminonucleoside-induced podocyte apoptosis is p53 dependent and time-dependent^[4]. PAN (Puromycin Aminonucleoside) treatment increased ER (endoplasmic reticulum) stress markers such as activating transcription factor (ATF) 6α and caspase-12 in a dose-dependent manner at 12 and 24 hours, respectively. PAN-induced ER stress increased oxidative stress and subsequently induced apoptosis, and could be mitigated by inhibition of PI3-kinase signaling^[5]. Rats given Puromycin aminonucleoside (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats. The pathogenesis of PAN toxicity is closely related to adenosine metabolism and that ADA (adenosine deaminase) plays a key role in this model^[6]. In PAN-treated MCs (mesangial cells), ERRα (estrogen-related receptor-α) overexpression further aggravated PAN-induced apoptosis^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3978 mL
- 16.9889 mL
- 33.9778 mL
- 5 mM
- 0.6796 mL
- 3.3978 mL
- 6.7956 mL
- 10 mM
- 0.3398 mL
- 1.6989 mL
- 3.3978 mL

技术信息

CAS号	58-60-6	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H18N6O3	运输	蓝冰
分子量	294.31	别名	NSC 3056;Puromycin Aminonucleoside;PANS;ARDMA;SAN;Stylomycin aminonucleoside;氨基核苷嘌呤霉素;嘌呤霉素氨基核苷

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