CAS No.: 868273-90-9
ONO-5334 Catalog No. CSN20340
Synonyms: ONO-5334
ONO-5334 is a potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00532337 Osteoporosis ... more >>Osteopenia Collapse << Phase 2 Completed - Netherlands ... more >> Andromed Noord Groningen Damsterdiep 9, Groningen, Netherlands Collapse << NCT01384188 Healthy Post Menopausal Women Phase 1 Phase 2 Completed - United Kingdom ... more >> Guildford Clinical Site Guildford, Surrey, United Kingdom, GU2 7XP London Clinical Site London, United Kingdom, SE1 1YR Collapse << - 参考文献
- [1] Tanaka M, Hashimoto Y, et al. Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis. BMC Musculoskelet Disord. 2017 Jun 19;18(1):267.
- [2] Nagase S, Ohyama M, et al. Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin K inhibitor, ONO-5334, in an ascending multiple-dose, phase 1 study. J Clin Pharmacol. 2012 Mar;52(3):306-18.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 868273-90-9 | 储存条件 |
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| 分子式 | C21H34N4O4S | 运输 | 蓝冰 | |
| 分子量 | 438.58 | 别名 | ONO-5334 |
