15966-93-5|SU5408|CsnPharm

CAS No.: 15966-93-5

SU5408/VEGFR2激酶抑制剂I Catalog No. CSN20516

Synonyms: VEGFR2 Kinase Inhibitor I

SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 VEGFR2 (murine)

IC50:70nM
描述Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. SU-5408, known as VEGFR2 Kinase Inhibitor I, is a potent, selective and cell-permeable inhibitor of mouse VEGFR2 kinase with IC50 value of 70 nM. SU5408 shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50>100 µM) ^[2]. 3-Substituted indolin-2-ones designed and synthesized as a novel class of tyrosine kinase inhibitors which show selectivity toward different receptor tyrosine kinases(RTKs). These compounds evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 is the most potent and selective VEGFR2 inhibitor among the compounds^[2].
参考文献

[1] Sun L, Tran N, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.
[2] Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. doi: 10.1021/jm980123i. PMID: 9651163.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2222 mL
- 16.1110 mL
- 32.2220 mL
- 5 mM
- 0.6444 mL
- 3.2222 mL
- 6.4444 mL
- 10 mM
- 0.3222 mL
- 1.6111 mL
- 3.2222 mL

技术信息

CAS号

15966-93-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18N2O3

运输

蓝冰

分子量

310.35

别名

VEGFR2 Kinase Inhibitor I

溶解度

DMSO	6.0 mg/mL (19.3 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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SU5408/VEGFR2激酶抑制剂I Catalog No. CSN20516

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