|(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-((((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊[a]菲-6-基)氧基)-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-甲基四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 52286-59-6

人参皂苷 Re Catalog No. CSN19488

Synonyms: 人参皂苷 Re;Ginsenoside B2;Panaxoside Re

Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.

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技术信息

生物活性

描述Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Re decreased the Aβ(β-amyloid protein) levels in N2a/APP695 cells. Ginsenoside Re decreased the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) mRNA and protein levels and inhibited BACE1 activity in the N2a/APP695 cells. Ginsenoside Re significantly increased the PPARγ protein and mRNA levels^[3]. Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1(transforming growth factor)/Smad3 pathway^[4]. GRe protects MA-induced (methamphetamine) dopaminergic neurotoxicity via upregulatgion of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated NK1 R (neurokinin 1 receptor) ^[5]. Moreover, ginsenoside Re-dependent upregulation of GPX4 (glutathione peroxidase 4) reduces oxidative stress and thereby alleviates 6-OHDA(6-hydroxydopamine)-induced neuronal damage^[6]. After GS-Re treatment, the vessel lumen of injured vessels showed significant increases in the GS-Re 25.0 and 50.0 mg/kg/d (intermediate- and high-dose) groups according to H.E. staining. GS-Re can suppress balloon injury-induced vascular neointimal hyperplasia by inhibiting VSMC proliferation^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02316730	Healthy	Phase 1	Completed	-	China, Sichuan ... more >> West China Second University Hospital Chengdu, Sichuan, China, 610000 Collapse <<
NCT02975076	Stroke, Acute ... more >> Ischemic Attack, Transient Collapse <<	Not Applicable	Not yet recruiting	November 2019	-
NCT00781534	Diabetes	Early Phase 1	Completed	-	United States, Missouri ... more >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0558 mL
- 5.2790 mL
- 10.5579 mL
- 5 mM
- 0.2112 mL
- 1.0558 mL
- 2.1116 mL
- 10 mM
- 0.1056 mL
- 0.5279 mL
- 1.0558 mL

技术信息

CAS号

52286-59-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C48H82O18

运输

蓝冰

分子量

947.15

别名

人参皂苷 Re;Ginsenoside B2;Panaxoside Re;Sanchinoside Re

溶解度

DMSO	98.0 mg/mL (103.5 mM)
Water	Insoluble
Ethanol	18.0 mg/mL (19.0 mM)

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