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CAS No.: 6882-68-4

Sophoridine/槐定碱 Catalog No. CSN20630

Synonyms: 5-Epidihydrosophocarpine;Dihydro-5-episophocarpine;Matrine

Sophoridine is naturally occuring alkaloid found in the plant Sophora flavescens, which could suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF‑κB and AP‑1 signaling pathway.

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技术信息

生物活性

描述Sophoridine is monomer alkaloids which extracts from Sophora alopecuroides L, is a potential antitumor natural product with high application value. Sophoridine exhibited remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μmol/L to 200 μmol/L^[3]. Moreover, the cell proliferation of difference concentrations Sophoridine treated groups(134.62 ± 5.76%, 98.96 ± 4.88%, 80.26 ± 6.70% and 80.08 ± 5.65%) was significantly reduced compared with 0 μg/ml group. And Sophoridine had suppressed Hep G2 proliferation with dose-depend^[4].
参考文献

[1] Wang B, Xu J, Wang H, Chang S, Liu N. Effect and Mechanism of Sophoridine to suppress Hepatocellular carcinoma in vitro and vivo. Biomed Pharmacother. 2017 Aug 28;95:324-330.
[2] Liang L, Wang XY, et al. Sophoridine exerts an anti-colorectal carcinoma effect through apoptosis induction in vitro and in vivo. Life Sci. 2012 Dec 17;91(25-26):1295-303.
[3] Xu Z, Zhang F, Bai C, Yao C, Zhong H, Zou C, Chen X. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11;36(1):124. doi: 10.1186/s13046-017-0590-5. Erratum in: J Exp Clin Cancer Res. 2020 Nov 26;39(1):263. PMID: 28893319; PMCID: PMC5594456.
[4] Wang B, Xu J, Wang H, Chang S, Liu N. Effect and Mechanism of Sophoridine to suppress Hepatocellular carcinoma in vitro and vivo. Biomed Pharmacother. 2017 Nov;95:324-330. doi: 10.1016/j.biopha.2017.08.029. Epub 2017 Sep 12. PMID: 28858730.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0264 mL
- 20.1318 mL
- 40.2635 mL
- 5 mM
- 0.8053 mL
- 4.0264 mL
- 8.0527 mL
- 10 mM
- 0.4026 mL
- 2.0132 mL
- 4.0264 mL

技术信息

CAS号

6882-68-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H24N2O

运输

蓝冰

分子量

248.36

别名

5-Epidihydrosophocarpine;Dihydro-5-episophocarpine;Matrine;(-)-Sophoridine;Sophoridin;l-Sophoridine;槐定碱

溶解度

DMSO	50.0 mg/mL (201.3 mM) warming

动物实验配方

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