|(R)-5-(N-(仲丁基)氨磺酰基)-N-(3,4-二氟苯基)-2-氟苯甲酰胺|CsnPharm

CAS No.: 1572510-80-5

AB-423 is Arbutus' first-generation capsid inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

描述The hepatitis B virus (HBV) is a non-cytopathic, small DNA virus of the Hepadnaviridae family with eight known HBV genotypes categorized from A to H based on sequence diversity. Ab-423, a SBA (sulfamoylbenzamide) class of HBV capsid assembly inhibitor, has inhibitory effect on HBV replication with EC₅₀ of 0.08-0.27 μM and EC₉₀ of 0.33-1.32 μM in living cells. AB-423 showed inhibition of rcDNA production in a concentration dependent manner in several different cell culture models of HBV. Specificly, the antiviral activity of AB-423 was comparable in the AML12-HBV10 and HepDE19 cell culture systems with EC₅₀ values of ~0.26 μM. Treatment of HepDES19 cells with 3 μM AB-423 for 6 days showed a strong inhibition of capsid associated RNA and DNA in comparison to untreated control cells indicating that AB-423 inhibited HBV replication at the step of pgRNA encapsidation. In a biochemical assay, AB-423 accelerated capsid assembly in a dose-responsive manner with an IC₅₀ of 2.9 μM. In vivo, AB-423 (30 or 100 mg/kg; p.o.) blocked HBV replication in a mouse model of HBV^[1].
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实验方案

技术信息

CAS号

1572510-80-5

储存条件

分子式

C17H17F3N2O3S

运输

蓝冰

分子量

386.39

别名

溶解度

动物实验配方

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