|((2R,3S,4R,5R)-3,4-二羟基-5-((Z)-4-(肟基)-2-氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-2-基)甲基异丁酸酯|CsnPharm

CAS No.: 2492423-29-5

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate Catalog No. CSN44050

Synonyms: EIDD-2801;MK-4482

Molnupiravir is an orally bioavailable form of a highly potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19.

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技术信息

生物活性

描述Molnupiravir (EIDD-2801) is an antiviral medication that inhibits the replication of certain RNA viruses. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease^[1]. Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever^[2]. It has recently been tested in COVID-19. 1600mg daily dose of molnupiravir is safe and tolerable, without any serious adverse events up to 5.5 days, and significantly lower time to clearance (RNA negative) with molnupiravir 800mg twice daily. The study also showed a significant reduction in the risk of hospital admission or death by 50% with the treatment of molnupiravir^[3].
参考文献

[1] Sheahan TP, Sims AC, Zhou S, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020;12(541):eabb5883.
[2] Toots M, Yoon JJ, Cox RM, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019;11(515):eaax5866.
[3] Singh AK, Singh A, Singh R, Misra A. Molnupiravir in COVID-19: A systematic review of literature. Diabetes Metab Syndr. 2021;15(6):102329.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0367 mL
- 15.1835 mL
- 30.3669 mL
- 5 mM
- 0.6073 mL
- 3.0367 mL
- 6.0734 mL
- 10 mM
- 0.3037 mL
- 1.5183 mL
- 3.0367 mL

技术信息

CAS号	2492423-29-5	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C13H19N3O7	运输	蓝冰
分子量	329.31	别名	EIDD-2801;MK-4482

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((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate Catalog No. CSN44050

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