|(1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-甲基 1,2,9-三羟基-8,11a-二甲基-4-((3-甲基丁-2-烯酰基)氧基)-5,10-二氧代-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-十二氢-1H-3,3a1-(环氧甲基)二苯并[de,g]苯并吡喃-3-羧酸酯|CsnPharm

CAS No.: 14907-98-3

(+)-Brusatol/鸦胆子苦醇 Catalog No. CSN13606

Synonyms: NSC 172924;鸦胆子苦醇;芸香醇

Brusatol is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 < 1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. < 50 nM in A549 cells), including NRF2.

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400-920-2911

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生物活性

描述Brusatol is a type of quassinoid obtained from Brucea javanica, an evergreen shrub grown in Southeast Asia. i>in vitro, under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1α degradation and cancer cell death in a dose-dependent manner^[3]. 0.5 μM brusatol significantly increased ROS accumulation after 24 h of treatment in pancreatic cancer cells^[4]. Brusatol treatment led to the pronounced loss of Nrf2 in mouse oocytes, which lead to oocyte maturation failure and spindle/chromosomal defects^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9211 mL
- 9.6057 mL
- 19.2113 mL
- 5 mM
- 0.3842 mL
- 1.9211 mL
- 3.8423 mL
- 10 mM
- 0.1921 mL
- 0.9606 mL
- 1.9211 mL

技术信息

CAS号

14907-98-3

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H32O11

运输

蓝冰

分子量

520.53

别名

NSC 172924;鸦胆子苦醇;芸香醇

溶解度

DMSO	133.33 mg/mL (256.2 mM)
Water	insoluble

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