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CAS No.: 518-34-3

粉防己碱 Catalog No. CSN16381

Synonyms: NSC-77037;d-Tetrandrine;Fanchinine

Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker that inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

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生物活性

描述Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals. The non-inactivating component of ICa was inhibited by external tetrandrine in a voltage- and dose-dependent manner, with an IC50 = 10.1 microM. IKCa was elicited by depolarizations when approximately 10 microM Ca2+ was present on the cytoplasmic side. Only externally applied tetrandrine, at 1 microM, decreased the amplitude of IKCa, whereas the fast inward Na+ current and transient outward K+ current were not affected^[3]. Tetrandrine enhanced the ubiquitination and degradation of Syk (spleen tyrosine kinase) and consequently repressed the osteoclastogenesis and bone destruction through the AhR-c-src-c-Cbl (aryl hydrocarbon receptor) pathway^[4]. Furthermore, Tetrandrine is a bisbenzylisoquinoline alkaloid known to exhibit anticancer activity against different cancers. Dose- and time-dependant cytotoxic effect of tetradrine on both MDA-MB-231 and PANC-1 cells (pancreatic PANC-1 and breast MDA-MB-231 cancer cells) with IC50 values ranging between 51 and 54 μM and 22 and 27 μM for 24 h and 48 h of incubation respectively^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6058 mL
- 8.0289 mL
- 16.0578 mL
- 5 mM
- 0.3212 mL
- 1.6058 mL
- 3.2116 mL
- 10 mM
- 0.1606 mL
- 0.8029 mL
- 1.6058 mL

技术信息

CAS号

518-34-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C38H42N2O6

运输

蓝冰

分子量

622.75

别名

NSC-77037;d-Tetrandrine;Fanchinine;Sinomenine A;(S,S)-(+)-tetrandrine;TTD;汉防己甲素;粉防己碱

溶解度

DMSO	1.0 mg/mL (1.6 mM) warming
Water	Insoluble
Ethanol	2.0 mg/mL (3.2 mM)

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