|(2E)-3-苯基-2-丙烯醛|CsnPharm

CAS No.: 14371-10-9

桂皮醛 Catalog No. CSN12125

Synonyms: 桂皮醛;反式肉桂醛

Trans-Cinnamaldehyde is a natural product isolated from cinnamon essential oil, role as a hypoglycemic agent, a phenylalanine ammonia-lyase inhibitor, a vasodilator agent, an antifungal agent, a flavouring agent, a plant metabolite and a sensitiser.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Cinnamic aldehyde (CA) is an electrophilic Nrf2 activator used in diabetic rodent models. Nrf2 is a transcription factor that regulates the antioxidant response. In primary ZDF (Zucker Diabetic Fatty) VSMC (vascular smooth muscle cell), CA inhibited cell growth by MTT with an EC50 of 118 ± 7 μM. At a therapeutic dose of 100 μM, CA inhibited proliferation of ZDF VSMC in vitro and reduced the proliferative index within the injured artery in vivo, as well as migration of ZDF VSMC in vitro. CA activated the Nrf2 pathway in both ZDF VSMC and injured carotid arteries while also increasing antioxidant defenses and reducing markers of redox dysfunction^[3]. Treatment with high doses of cinnamic aldehyde (45, 90 mg/kg) reversed the behavioral abnormalities, and decreased the COX-2 protein and activity (but not COX-2 mRNA expression) and PGE2 (prostaglandin E2) concentration in frontal cortex and hippocampus of stressed rats. Cinnamic aldehyde exerted antidepressant-like effects in stressed mid-aged rats, and its mechanism of action appears to decrease COX-2 protein and activity^[4]. CA has a neuroprotective effect in a Parkinson's disease model^[5]. CA administration inhibits tumor growth and blocks tumor angiogenesis in BALB/c mice. In addition, CA treatment decreased HIF-1α protein expression and vascular endothelial growth factor (VEGF) expression in mouse tumors and Renca cells exposed to hypoxia in vitro^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02653703	Inflammation ... more >>Pruritus Hyperalgesia Collapse <<	Not Applicable	Completed	-	-
NCT03132142	Pain Pruritus... more >> Neuropathic Pain Dermatology/Skin - Other Collapse <<	Not Applicable	Recruiting	August 2017	Denmark ... more >> SMI Recruiting Aalborg, Denmark, 9000 Contact: Hjalte H Andersen, MSc. Med. 0045 24464515 hha@hst.aau.dk Sub-Investigator: Jens B Marker, BSc. Med. Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.5666 mL
- 37.8329 mL
- 75.6659 mL
- 5 mM
- 1.5133 mL
- 7.5666 mL
- 15.1332 mL
- 10 mM
- 0.7567 mL
- 3.7833 mL
- 7.5666 mL

技术信息

CAS号	14371-10-9	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H8O	运输	蓝冰
分子量	132.16	别名	桂皮醛;反式肉桂醛

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

桂皮醛 Catalog No. CSN12125

靶点选择性

请登录您的专属账户

确认信息