|(2R,3R)-2-(3,4-二羟基苯基)-5,7-二羟基-3-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)苯并吡喃-4-酮|CsnPharm

CAS No.: 29838-67-3

落新妇苷 Catalog No. CSN15955

Synonyms: Isoastilbin;Neoastilbin;Neoisoastilbin

Astilbin is a flavonoid compound that can enhance NRF2 activition with anti-inflammatory properties. It could be extracted from chinese astilbe. Astilbin has been found to have significant immunosuppressive effects in recent years.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Astilbin, a flavonoid compound, is isolated from the rhizome of Smilax glabra. Astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin could ameliorate the cisplatin-induced nephrotoxicity by reducing oxidative stress and inflammation^[3]. In addition, kidney function parameters, including serum creatinine (Scr) and blood urea nitrogen (BUN) were restored in astilbin-treated hyperuricemic rats. Astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor κB (NLRP3/NF-κB), which is associated with the up-regulation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress^[4]. Astilbin may be a promising agent for psoriasis treatment. Astilbin leads to S phase arrest of the cell cycle by induction of p53 and p21 and activated-AMPK. Moreover, astilbin regulates the expression of VEGF in human HaCaT keratinocytes^[5]. The absolute bioavailability of astilbin was improved from 0.32 to 4.40% in rats through nanoparticle fabrication^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2203 mL
- 11.1014 mL
- 22.2028 mL
- 5 mM
- 0.4441 mL
- 2.2203 mL
- 4.4406 mL
- 10 mM
- 0.2220 mL
- 1.1101 mL
- 2.2203 mL

技术信息

CAS号

29838-67-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22O11

运输

蓝冰

分子量

450.39

别名

Isoastilbin;Neoastilbin;Neoisoastilbin;Taxifolin 3-O-rhamnoside;Taxifolin 3-rhamnoside;落新妇苷

溶解度

DMSO	100.0 mg/mL (222.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

落新妇苷 Catalog No. CSN15955

靶点选择性

请登录您的专属账户

确认信息