生物活性

• 描述Deoxynojirimycin (1-Deoxynojirimycin) HCl, a natural product isolated and purified from the root barks of Morus alba L., shows inhibitory activity against α-glucosidases, inhibitors of α-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs^[3]. Hypoglycemic agent DNJ could suppress the adipogenesis during the differentiation of white preadipocytes, and promote the switch of white preadipocytes to beige adipocytes via activating AMPK^[4]. DNJ can increase hepatic insulin sensitivity via strengthening of the insulin-stimulated PKB/GSK-3β signal pathway and by modulating glucose metabolic enzymes in db/db mice. Moreover, DNJ also can improve lipid homeostasis and attenuate hepatic steatosis in db/db mice^[5]. Caloric restriction and 1-deoxynojirimycin inhibit growth of colorectal cancer by inducing apoptosis in an induced cancer model in mice^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01380743	Pompe Disease	Phase 2	Completed	-	United States, Arizona ... more >> Phoenix, Arizona, United States, 85018 Scottsdale, Arizona, United States, 85258 United States, California Orange, California, United States, 92868 United States, Florida Gainesville, Florida, United States, 32610 United States, Georgia Decatur, Georgia, United States, 30033 United States, Kansas Kansas City, Kansas, United States, 66160 United States, Montana Great Falls, Montana, United States, 59405 United States, North Carolina Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati, Ohio, United States, 45299 United States, Oregon Portland, Oregon, United States, 97239 United States, Virginia Springfield, Virginia, United States, 22152 Canada, Ontario Hamilton, Ontario, Canada, L8N 3Z5 France Paris, France, 75013 United Kingdom London, Queen Square, United Kingdom, WC1N 3BG Salford, United Kingdom, M68 HD Collapse <<
  NCT01853852	Fabry Disease	Phase 1	Completed	-	Australia, New South Wales ... more >> GSK Investigational Site Randwick, New South Wales, Australia, 2031 Collapse <<
  NCT02194985	Fabry Disease	Phase 3	Active, not recruiting	October 2019	-

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• 参考文献

• [1] Warfield KL, Plummer EM, et al. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4. Antiviral Res. 2016 May;129:93-8.

  [2] Ma CM, Hattori M, et al. Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors. J Med Chem. 2008 Oct 9;51(19):6188-94.

  [3] Hong KQ, Fu XM, Yin H, Li ST, Chen T, Wang ZW. Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin. Crit Rev Anal Chem. 2021;51(3):246-257

  [4] Li AN, Chen JJ, Li QQ, Zeng GY, Chen QY, Chen JL, Liao ZM, Jin P, Wang KS, Yang ZC. Alpha-glucosidase inhibitor 1-Deoxynojirimycin promotes beige remodeling of 3T3-L1 preadipocytes via activating AMPK. Biochem Biophys Res Commun. 2019 Feb 19;509(4):1001-1007

  [5] Liu Q, Li X, Li C, Zheng Y, Wang F, Li H, Peng G. 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. Molecules. 2016 Feb 27;21(3):279

  [6] E S, Yamamoto K, Sakamoto Y, Mizowaki Y, Iwagaki Y, Kimura T, Nakagawa K, Miyazawa T, Tsuduki T. Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. J Clin Biochem Nutr. 2017 Jul;61(1):47-52

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