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CAS No.: 34157-83-0
Synonyms: Tripterine;TripterinTripterinTripterinTripterinTripterin;雷公藤红素
Celastrol is an inhibitor of HSP90 with antioxidant and anti-inflammatory activities.
生物活性
实验方案
技术信息
CAS号 | 34157-83-0 | 储存条件 |
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分子式 | C29H38O4 | 运输 | 蓝冰 | |||||
分子量 | 450.61 | 别名 | Tripterine;TripterinTripterinTripterinTripterinTripterin;雷公藤红素 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HeLa cells | - | Function assay | - | Inhibition of NF-kappaB activity in human HeLa cells by SEAP reporter assay, IC50=0.15 μM | 20469887 |
HeLa cells | - | Function assay | 3 h | Amplification of HSF1 transcriptional activity in human HeLa cells assessed as granule formation pretreated for 3 hrs by immunocytochemical staining, EC50=2.6 μM | 19502057 |
human 293T cells | - | Function assay | 30 mins | Inhibition of LPS-induced NF-kappaB activation in human 293T cells incubated for 30 mins followed by treated with LPS for 6 hrs by dual-luciferase reporter assay, IC50=0.17 μM | 21393004 |
human 293T cells | - | Cytotoxic assay | - | Cytotoxicity against human 293T cells assessed as cell viability by dual-luciferase reporter assay, IC50=0.67 μM | 21393004 |
human HeLa cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human HeLa cells after 72 hrs by MTS assay, IC50=3 μM | 19502057 |
human HepG2 cells | - | Function assay | 48 h | Anticancer activity against human HepG2 cells assessed as cell survival after 48 hrs by MTT assay, IC50=4.01 μM | 25812966 |
human LNCAP cells | - | Function assay | - | Antitumor activity against human LNCAP cells, IC50=2.5 μM | 20627556 |
human MCF7 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay, IC50=0.153 μM | 25756299 |
human MCF7 cells | - | Function assay | 24 h | Inhibition of HSP90 in human MCF7 cells assessed as Raf degradation at 5 times IC50 after 24 hrs by Western blot analysis | 25756299 |
human MGC803 cells | - | Function assay | 48 h | Anticancer activity against human MGC803 cells assessed as cell survival after 48 hrs by MTT assay, IC50=1.55 μM | 25812966 |
human NCI-H460 cells | - | Cytotoxic assay | - | Cytotoxicity against human NCI-H460 cells after overnight incubation by MTT assay, IC50=12.3 μM | 21942765 |
human RPMI8226 cells | - | Growth inhibition assay | - | Growth inhibition of human RPMI8226 cells, IC50=3 μM | 18164197 |
human SGC7901 cells | - | Function assay | 48 h | Anticancer activity against human SGC7901 cells assessed as cell survival after 48 hrs by MTT assay, IC50=0.15 μM | 25812966 |
human SH-SY5Y cells | - | Function assay | - | Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release, EC50=0.03764 μM | 19138859 |
human SK-N-SH cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human SK-N-SH cells after 72 hrs by MTS assay, CC50=1.6 μM | 19502057 |
human SMMC7721 cells | - | Function assay | 48 h | Anticancer activity against human SMMC7721 cells assessed as cell survival after 48 hrs by MTT assay, IC50=0.58 μM | 25812966 |
human THP1 cells | - | Function assay | 24 h | Induction of apoptosis in TRAIL-resistant human THP1 cells after 24 hrs by annexin-V staining, EC50=15 μM | 20864342 |
mouse RAW264.7 cells | - | Function assay | 18 h | Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells after 18 hrs by luciferase reporter gene assay, IC50=0.2 μM | 22705020 |
rat PC12 cells | - | Function assay | - | Cytoprotective activity against t-BPH-induced cell damage in rat PC12 cells assessed as cell viability, IC50=3.15 μM | 20627556 |
靶点 | Description | IC50 |
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