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CAS No.: 78613-38-4

盐酸阿莫罗芬 Catalog No. CSN10294

Synonyms: 盐酸阿莫罗芬;Ro 14-4767/002

Amorolfine HCl is a morpholine antifungal drug working by inhibiting Δ-sterol reductase.

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技术信息

生物活性

描述Amorolfine Hydrochloride is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species. Amorolfine clears mycotic foci of trichophytosis in the guinea pig in 10 days, while none of the azoles is able to cure these animals. In vaginal candidosis 0.1% amorolfine clears the vagina of viable candida cells in rats^[3]. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. The results suggest that this novel combination of enhancers has the potential to be an effective option for topical drug delivery through the nail, and increased the efficacy of treatment^[4]. In clinical trials, application of amorolfine 5% nail lacquer once or twice weekly for up to 6 months produced mycological and clinical cure in approximately 40 to 55% of patients with mild onychomycosis 3 months after cessation of therapy. Overall cure and improvement was observed in approximately 85 to 90% of patients with superficial dermatomycoses following treatment with amorolfine 0.25% cream for up to 6 weeks^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02321098	Foot Dermatoses	Phase 4	Completed	-	Iceland ... more >> Principal Investigator Reykjavik, Iceland Collapse <<
NCT03289871	Onychomycosis	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<
NCT03382717	Onychomycosis of Toenail	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8251 mL
- 14.1255 mL
- 28.2510 mL
- 5 mM
- 0.5650 mL
- 2.8251 mL
- 5.6502 mL
- 10 mM
- 0.2825 mL
- 1.4126 mL
- 2.8251 mL

技术信息

CAS号

78613-38-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H36ClNO

运输

蓝冰

分子量

353.97

别名

盐酸阿莫罗芬;Ro 14-4767/002

溶解度

DMSO	27.0 mg/mL (76.3 mM)
Ethanol	70.0 mg/mL (197.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02321098	Foot Dermatoses	Phase 4	Completed	-	Iceland ... more >> Principal Investigator Reykjavik, Iceland Collapse <<
NCT03289871	Onychomycosis	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<
NCT03382717	Onychomycosis of Toenail	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<
NCT02321098	-	-	Completed	-	-
NCT00938925	Onychomycosis	Phase 1	Suspended(No funds)	March 2017	Spain ... more >> School Health Sciences, University of Malaga Malaga, Málaga, Spain, 29009 Antonio Cuesta-vargas Malaga, Spain, 29009 Health Science School , University of Malaga Malaga, Spain, 29009 Collapse <<
NCT02679911	Foot Dermatoses	Phase 4	Completed	-	Germany ... more >> Tübingen, Germany Collapse <<
NCT02549001	Onychomycosis	Phase 3	Completed	-	Belgium ... more >> Polichem Investigative Site Multiple Locations, Belgium Bulgaria Polichem Investigative Site Multiple Locations, Bulgaria Czechia Polichem Investigative Site Multiple Locations, Czechia Germany Polichem Investigative Site Multiple Locations, Germany Greece Polichem Investigative Site Multiple Locations, Greece Hungary Polichem Investigative Site Multiple Locations, Hungary Iceland Polichem Investigative Site Various Cities In Iceland, Iceland Latvia Polichem Investigative Site Multiple Locations, Latvia Lithuania Polichem Investigative Site Multiple Locations, Lithuania Poland Polichem Investigative Site Multiple Locations, Poland Russian Federation Polichem Investigative Site Multiple Locations, Russian Federation Slovakia Polichem Investigative Site Multiple Locations, Slovakia Sweden Polichem Investigative Site Multiple Locations, Sweden Collapse <<
NCT02679911	-	-	Completed	-	-
NCT02705664	Foot Dermatoses	Phase 4	Completed	-	Iceland ... more >> Principal Investigator Reykjavik, Iceland Collapse <<
NCT01528813	Onychomycosis	Phase 2	Unknown	December 2013	Brazil ... more >> University Hospital of Brasilia Recruiting Brasilia, Federal District, Brazil, 70910-900 Contact: Orlando O Morais, M.D. +55(61)99162339 orlando.unb@gmail.com Principal Investigator: Orlando O Morais, M.D. Collapse <<
NCT00459537	Onychomycosis	Phase 3	Completed	-	Finland ... more >> Novartis Investigative Site Various Cities, Finland France Novartis Investigative Site Various Cities, France Germany Novartis Investigative Site Various Cities, Germany Hungary Novartis Investigative Site Various Cities, Hungary Iceland Novartis Investigative Site Various Cities, Iceland Norway Novartis Investigative Site Various Cities, Norway Poland Novartis Investigative Site Various Cities, Poland Russian Federation Novartis Investigative Site Various Cities, Russian Federation Spain Novartis Investigative Site Various Cities, Spain Turkey Novartis Investigative Site Various Cities, Turkey Collapse <<
NCT03098342	Onychomycosis of Toenail	Not Applicable	Not yet recruiting	January 31, 2019	Thailand ... more >> King Chulalongkorn Memorial Hospital Not yet recruiting Bangkok, Thailand, 10330 Contact: Nutthamon Bowornsathitchai, M.D. 66818239488 bee_o_bo@hotmail.com Contact: Jaruwan Pemcharoen, B.Sc. 66823573912 photochulateam@gmail.com Sub-Investigator: Anukorn Sriaram, B.Eng. Collapse <<
NCT00459537	-	-	Completed	-	-
NCT01014637	Onychomycosis	Phase 4	Unknown	September 2011	France ... more >> Cabinet Médical Recruiting Argenteuil, France, 95100 Principal Investigator: Yves LE CORRE, MD Cabinet Médical Recruiting Brest, France, 29200 Principal Investigator: Monique CHASSAIN LE LAY, MD Cabinet Medical Recruiting Cholet, France, 49300 Principal Investigator: Jean-Michel DEBARRE, MD Cabinet Médical Recruiting Martigues, France, 13500 Principal Investigator: Mireille RUER-MULLARD, MD Cabinet Médical Recruiting Nice, France, 06000 Principal Investigator: Gilles ROSTAIN, MD Cabinet Médical Recruiting Toulouse, France, 31000 Principal Investigator: Didier COUSTOU, MD Hopital Purpan Not yet recruiting Toulouse, France Principal Investigator: Carle PAUL, Professor Collapse <<
NCT01851590	Onychomycosis	Phase 4	Completed	-	Finland ... more >> Vääksyn Lääkärikeskus Vääksy, Finland, FI-17200 Collapse <<
NCT02812043	Non-dermatophyte Onychomycosis	Phase 4	Recruiting	August 2018	Thailand ... more >> Department of Dermatology Siriraj Hospital Recruiting Bangkoknoi, Bangkok, Thailand, 10700 Contact: Charussri Leeyaphan, MD 6624194333 charussrilee@gmail.com Collapse <<
NCT01929187	Onycomycosis	Not Applicable	Unknown	July 2014	Taiwan ... more >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Chiu-Nun Chen +886+2-23562141 derm@ntuh.gov.tw Principal Investigator: Jin-Bon Hong, MD Collapse <<
NCT01851590	-	-	Completed	-	-
NCT02321098	Foot Dermatoses	Phase 4	Completed	-	Iceland ... more >> Principal Investigator Reykjavik, Iceland Collapse <<
NCT02321098	-	-	Completed	-	-
NCT03382717	Onychomycosis of Toenail	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<
NCT00938925	Onychomycosis	Phase 1	Suspended(No funds)	March 2017	Spain ... more >> School Health Sciences, University of Malaga Malaga, Málaga, Spain, 29009 Antonio Cuesta-vargas Malaga, Spain, 29009 Health Science School , University of Malaga Malaga, Spain, 29009 Collapse <<
NCT02549001	Onychomycosis	Phase 3	Completed	-	Belgium ... more >> Polichem Investigative Site Multiple Locations, Belgium Bulgaria Polichem Investigative Site Multiple Locations, Bulgaria Czechia Polichem Investigative Site Multiple Locations, Czechia Germany Polichem Investigative Site Multiple Locations, Germany Greece Polichem Investigative Site Multiple Locations, Greece Hungary Polichem Investigative Site Multiple Locations, Hungary Iceland Polichem Investigative Site Various Cities In Iceland, Iceland Latvia Polichem Investigative Site Multiple Locations, Latvia Lithuania Polichem Investigative Site Multiple Locations, Lithuania Poland Polichem Investigative Site Multiple Locations, Poland Russian Federation Polichem Investigative Site Multiple Locations, Russian Federation Slovakia Polichem Investigative Site Multiple Locations, Slovakia Sweden Polichem Investigative Site Multiple Locations, Sweden Collapse <<
NCT03289871	Onychomycosis	Not Applicable	Completed	-	Tunisia ... more >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia Collapse <<
NCT02679911	Foot Dermatoses	Phase 4	Completed	-	Germany ... more >> Tübingen, Germany Collapse <<
NCT01528813	Onychomycosis	Phase 2	Unknown	December 2013	Brazil ... more >> University Hospital of Brasilia Recruiting Brasilia, Federal District, Brazil, 70910-900 Contact: Orlando O Morais, M.D. +55(61)99162339 orlando.unb@gmail.com Principal Investigator: Orlando O Morais, M.D. Collapse <<
NCT02705664	Foot Dermatoses	Phase 4	Completed	-	Iceland ... more >> Principal Investigator Reykjavik, Iceland Collapse <<
NCT02679911	-	-	Completed	-	-
NCT00459537	Onychomycosis	Phase 3	Completed	-	Finland ... more >> Novartis Investigative Site Various Cities, Finland France Novartis Investigative Site Various Cities, France Germany Novartis Investigative Site Various Cities, Germany Hungary Novartis Investigative Site Various Cities, Hungary Iceland Novartis Investigative Site Various Cities, Iceland Norway Novartis Investigative Site Various Cities, Norway Poland Novartis Investigative Site Various Cities, Poland Russian Federation Novartis Investigative Site Various Cities, Russian Federation Spain Novartis Investigative Site Various Cities, Spain Turkey Novartis Investigative Site Various Cities, Turkey Collapse <<
NCT01014637	Onychomycosis	Phase 4	Unknown	September 2011	France ... more >> Cabinet Médical Recruiting Argenteuil, France, 95100 Principal Investigator: Yves LE CORRE, MD Cabinet Médical Recruiting Brest, France, 29200 Principal Investigator: Monique CHASSAIN LE LAY, MD Cabinet Medical Recruiting Cholet, France, 49300 Principal Investigator: Jean-Michel DEBARRE, MD Cabinet Médical Recruiting Martigues, France, 13500 Principal Investigator: Mireille RUER-MULLARD, MD Cabinet Médical Recruiting Nice, France, 06000 Principal Investigator: Gilles ROSTAIN, MD Cabinet Médical Recruiting Toulouse, France, 31000 Principal Investigator: Didier COUSTOU, MD Hopital Purpan Not yet recruiting Toulouse, France Principal Investigator: Carle PAUL, Professor Collapse <<
NCT01929187	Onycomycosis	Not Applicable	Unknown	July 2014	Taiwan ... more >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Chiu-Nun Chen +886+2-23562141 derm@ntuh.gov.tw Principal Investigator: Jin-Bon Hong, MD Collapse <<
NCT01851590	Onychomycosis	Phase 4	Completed	-	Finland ... more >> Vääksyn Lääkärikeskus Vääksy, Finland, FI-17200 Collapse <<
NCT00459537	-	-	Completed	-	-
NCT03098342	Onychomycosis of Toenail	Not Applicable	Not yet recruiting	January 31, 2019	Thailand ... more >> King Chulalongkorn Memorial Hospital Not yet recruiting Bangkok, Thailand, 10330 Contact: Nutthamon Bowornsathitchai, M.D. 66818239488 bee_o_bo@hotmail.com Contact: Jaruwan Pemcharoen, B.Sc. 66823573912 photochulateam@gmail.com Sub-Investigator: Anukorn Sriaram, B.Eng. Collapse <<
NCT01851590	-	-	Completed	-	-
NCT02812043	Non-dermatophyte Onychomycosis	Phase 4	Recruiting	August 2018	Thailand ... more >> Department of Dermatology Siriraj Hospital Recruiting Bangkoknoi, Bangkok, Thailand, 10700 Contact: Charussri Leeyaphan, MD 6624194333 charussrilee@gmail.com Collapse <<

盐酸阿莫罗芬 Catalog No. CSN10294

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