|(2S,3R)-2-氨基-4-羟基-3-甲基戊酸|CsnPharm

CAS No.: 781658-23-9

4-羟基-L-异亮氨酸 Catalog No. CSN12945

Synonyms: 4-羟基-L-异亮氨酸;4-Hydroxy-L-isoleucine;L-4-羟基异亮氨酸

L-4-Hydroxyisoleucine, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L., acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述L-4-Hydroxyisoleucine (4-HIL) is a new type of insulin secretion enhancer and can be used in the treatment of type 2 diabetes. L-4-hydroxyisoleucine is a non-protein amino acid in fenugreek. This amino acid mainly exists in fenugreek seeds, accounting for about 80% of the total free amino acids in the seeds. 4-Hydroxyisoleucine (4-HIL) exhibits a unique glucose-dependent insulinotropic activity and is a promising candidate for the treatment of diabetes. Six genes involved in oxaloacetate and α-ketoglutarate branches were overexpressed or deleted, which increased the production of 4-HIL to 5.12 g/L but a considerable amount of L-isoleucine still accumulated in the culture^[3]. 4-HIL significantly repressed the mRNA and protein levels of iRhom2 and TACE in RAW264.7 macrophages after LPS stimulated. Meanwhile, the levels of pro-inflammatory cytokines, including TNF-α, MCP-1, and IL-6, were substantially suppressed by 4-HIL in the co-culture system^[4]. 4-HIL directly or indirectly reversed TNF-α reduced glycogen levels by inhibiting JNK and IRS-1 (Ser(307)) phosphorylation and increasing AKT (Ser(473)) and GSK-3 phosphorylation^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.7948 mL
- 33.9738 mL
- 67.9476 mL
- 5 mM
- 1.3590 mL
- 6.7948 mL
- 13.5895 mL
- 10 mM
- 0.6795 mL
- 3.3974 mL
- 6.7948 mL

技术信息

CAS号

781658-23-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H13NO3

运输

蓝冰

分子量

147.17

别名

4-羟基-L-异亮氨酸;4-Hydroxy-L-isoleucine;L-4-羟基异亮氨酸

溶解度

DMSO	insoluble
Water	150.0 mg/mL (1019.2 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

4-羟基-L-异亮氨酸 Catalog No. CSN12945

靶点选择性

请登录您的专属账户

确认信息