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CAS No.: 27208-80-6

虎杖苷 Catalog No. CSN19413

Synonyms: Piceid;(E)-Piceid;trans-Resveratrol-3-O-β-D-Glucopyranoside

Polydatin, extracted from the roots ofPolygonum cuspidatumSieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models.

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400-920-2911

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技术信息

生物活性

描述Polydatin, a resveratrol glucoside is an active component isolated from the roots of Polygonum. Administration of polydatin for 3w and 6w significant attenuated liver histology damage and inflammatory cell infiltration^[3]. in vitro, polydatin(0, 50, 100, 150 μM) effectively inhibited cell proliferation of Caco-2 and HCT 116 cells and promoted cell apoptosis in CRC cell lines. Moreover, the expression of PD-L1 was dramatically reduced after treatment of Polydatin (100 μM), whereas this inhibitory effect was attenuated by downregulation of miR-382^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02372903	Endometriosis ... more >> Chronic Pelvic Pain Collapse <<	Not Applicable	Completed	-	Italy ... more >> University of Cagliari,Obstetrics and Gynecological Department, Monserrato, Cagliari, Italy, 09042 Collapse <<
NCT01780129	Shock, Hemorrhagic ... more >> Shock, Traumatic Shock, Septic Collapse <<	Phase 2	Unknown	December 2014	United States, Delaware ... more >> Christiana Care Not yet recruiting Newark, Delaware, United States, 19718 Contact: GERARD FULDA, PhD 302-733-4260 gfulda@christianacare.org Principal Investigator: GERARD FULDA, PhD Collapse <<
NCT01370720	Irritable Bowel Syndrome	Phase 2	Unknown	January 2013	Italy ... more >> Dept Internal Medicine and Gastroenterology, Policlinico Sant'Orsola-Malpighi Recruiting Bologna, Italy, I-40138 Contact: Vincenzo Stanghellini, MD +39 051 6364101 Prof. Vincenzo Stanghellini Contact: Rosanna Cogliandro, MD +39 051 6364103 rosanna.cogliandro@aosp.bo.it Principal Investigator: Vincenzo Stanghellini, MD Collapse <<

参考文献

[1] Cheng Y, Zhang HT, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Res. 2006 Sep 19;1110(1):193-200.
[2] Wang HL, Cui XH, et al. Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):280-291.
[3] Zhao X, Li R, Liu Y, Zhang X, Zhang M, Zeng Z, Wu L, Gao X, Lan T, Wang Y. Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice. Arch Biochem Biophys. 2017 Sep 1;629:1-7. doi: 10.1016/j.abb.2017.06.017. Epub 2017 Jun 27. PMID: 28666738.
[4] Jin Y, Zhan X, Zhang B, Chen Y, Liu C, Yu L. Polydatin Exerts an Antitumor Effect Through Regulating the miR-382/PD-L1 Axis in Colorectal Cancer. Cancer Biother Radiopharm. 2020 Mar;35(2):83-91. doi: 10.1089/cbr.2019.2999. Epub 2019 Nov 22. PMID: 31755739.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5616 mL
- 12.8079 mL
- 25.6158 mL
- 5 mM
- 0.5123 mL
- 2.5616 mL
- 5.1232 mL
- 10 mM
- 0.2562 mL
- 1.2808 mL
- 2.5616 mL

技术信息

CAS号

27208-80-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22O8

运输

蓝冰

分子量

390.38

别名

Piceid;(E)-Piceid;trans-Resveratrol-3-O-β-D-Glucopyranoside;3,4,5-Tsg;3,4,5-Trihydroxystilbene-3-beta-monoglucoside;虎杖苷

溶解度

DMSO	28.0 mg/mL (71.7 mM)

动物实验配方

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