生物活性

• 描述Enoxolone is Gap junction inhibitor and a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti-microbial activities.In vitro， this Enoxolone derivative did not cause cell death, but significantly enhanced the proliferation of dermal fibroblasts and HaCaT keratinocytes. A scratch wound healing assay revealed that the Enoxolone derivative promoted the migration of fibroblasts^[3]. In vivo，histological data also indicated Enoxolone has no effects on inflammatory joint destruction^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00686881	Hepatitis C, Chronic	Phase 3	Terminated(This study was term... more >>inated due to low enrollment) Collapse <<	-	-
  NCT03051048	-	-	Completed	-	China, Jiangsu ... more >> Changshu First People's Hospital Changshu, Jiangsu, China Changzhou Traditional Chinese Medicine Hospital Changzhou, Jiangsu, China Jintan People's Hospital Jintan, Jiangsu, China Liyang Hospital of TCM Liyang, Jiangsu, China Gaochun People's Hospital Nanjing, Jiangsu, China China Anqing First People's Hospital Anqing, China The 123 Hospital of PLA Bengbu, China Changzhou Fouth People's Hospital Changzhou, China Huaian Second People's Hospital Huai'an, China Huainan Eastern Hospital Huainan, China Huainan Xinhua Hospital Huainan, China Maanshan Shiqiye Hospital Ma'anshan, China Muyang Traditional Chinese Medicine Hospital Muyang, China Nanjing First Hospital Nanjing, China Nanjing Pukou Central Hospital Nanjing, China Nnajing 81 Hospital Nanjing, China Nnajing Integrated Traditional Chinese and Westem Medicine Hospital Nanjing, China Taicang First People's Hospital Taicang, China Wuxi Third Hospital Wuxi, China Yixin People's Hospital Wuxi, China Yixing Traditional Chinese Medicine Hospital Wuxi, China Xuncheng Central Hospital Xuancheng, China Zhangjiagang First People's Hospital Zhangjiagang, China Collapse <<
  NCT01649947	Non-small Cell Lung Cancer ... more >> Advanced Non-small Cell Lung Cancer Recurrent Non-small Cell Lung Cancer Collapse <<	Phase 2	Completed	-	United States, New Jersey ... more >> Robert Wood Johnson University Hospital at Hamilton Hamilton, New Jersey, United States, 08690 Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08901 Collapse <<

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• 参考文献

• [1] Zhu J, Chen M, et al. Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. Int J Oncol. 2015 Mar;46(3):981-8.

  [2] Pirzadeh S, Fakhari S, et al. Glycyrrhetinic Acid Induces Apoptosis in Leukemic HL60 Cells Through Upregulating of CD95/ CD178. Int J Mol Cell Med. 2014 Fall;3(4):272-8.

  [3] Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL. 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. PLoS One. 2017 Aug 16;12(8):e0182981. doi: 10.1371/journal.pone.0182981. PMID: 28813533; PMCID: PMC5558956.

  [4] Puchner A, Hayer S, Niederreiter B, Hladik A, Blueml S, Bonelli M, Scheinecker C, Smolen J, Redlich K. Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. Wien Klin Wochenschr. 2012 Mar;124(5-6):170-6. doi: 10.1007/s00508-011-0103-z. Epub 2012 Jan 3. PMID: 22210441.