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CAS No.: 57-48-7

D-果糖 Catalog No. CSN25433

Synonyms: D-果糖;D(-)-Fructose;D-(-)-Levulose

D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.

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技术信息

生物活性

描述E-Fructose is a rare monosaccharide that exists in extremely small quantities in nature, and it is also hard to prepare at a large scale via chemical or enzyme synthetic route due to low conversion and downstream separation complexity^[1]. Importantly, a d-fructose decoration of 16% renders the polymers water-soluble and eliminates the cytotoxicity of PEI in noncancer L929 cells, accompanied by a reduced unspecific cellular uptake of the genetic material. The introduction of d-fructose shows superior potential for cell targeting, which can be assumed to be GLUT5 dependent^[2]. Tracer D-[14C]-fructose uptake rate was reduced to 54.8% in 50 mM d-allulose and to 16.4% in 50 mM d-fructose, suggesting d-allulose competed with D-[14C]-fructose and the affinity of d-allulose for GLUT5 was lower than that of d-fructose. GLUT5 clearly mediates, likely at lower affinity relative to d-fructose, intestinal d-allulose transport^[3]. The adsorbed-FDH electrodes catalyzed the electrochemical two-electron oxidation of d-fructose to 5-keto-d-fructose without a mediator. Nanostructured carbon particle-modified electrodes were used for the coulometric d-fructose biosensor to enhance the catalytic current density. The electric charge for the d-fructose oxidation gained by the biocoulometric measurement was in good agreement with the theoretical value corresponding to d-fructose amount in the range from 1 to 100 mM with a sample volume of 1 muL^[4].
参考文献

[1] Xiao Q, Niu J, Liu H, Liu Y, Zhou X. High Conversion of D-Fructose into D-Allulose by Enzymes Coupling with an ATP Regeneration System. Mol Biotechnol. 2019;61(6):432‐441
[2] Englert C, Pröhl M, Czaplewska JA, et al. d-Fructose-Decorated Poly(ethylene imine) for Human Breast Cancer Cell Targeting. Macromol Biosci. 2017;17(8):10.1002/mabi.201600502
[3] Kishida K, Martinez G, Iida T, Yamada T, Ferraris RP, Toyoda Y. d-Allulose is a substrate of glucose transporter type 5 (GLUT5) in the small intestine. Food Chem. 2019;277:604‐608
[4] Tsujimura S, Nishina A, Kamitaka Y, Kano K. Coulometric D-fructose biosensor based on direct electron transfer using D-fructose dehydrogenase. Anal Chem. 2009;81(22):9383‐9387

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.5507 mL
- 27.7537 mL
- 55.5075 mL
- 5 mM
- 1.1101 mL
- 5.5507 mL
- 11.1015 mL
- 10 mM
- 0.5551 mL
- 2.7754 mL
- 5.5507 mL

技术信息

CAS号

57-48-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H12O6

运输

蓝冰

分子量

180.16

别名

D-果糖;D(-)-Fructose;D-(-)-Levulose

溶解度

Water

250.0 mg/mL (1387.7 mM) warming

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