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CAS No.: 54-47-7

磷酸吡哆醛 Catalog No. CSN23400

Synonyms: Pyridoxal 5′-phosphate;Pyridoxyl phosphate;MC-1

Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

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400-920-2911

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技术信息

生物活性

描述Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi^[1]. Increasing Mg2+ concentration up to 14 mM overcame the suppression of self-splicing by pyridoxal phosphate up to 95% of the level of normal splicing, implying its interference with effective catalysis of Mg2+. The kinetic analysis demonstrated that pyridoxal phosphate acts as a mixed type noncompetitive inhibitor for the td intron RNA with a K(i) of 11.8 mM^[2]. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost^[3].
参考文献

[1] Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP. Pyridoxal phosphate: biosynthesis and catabolism. Biochim Biophys Acta. 2011 Nov;1814(11):1585-96
[2] Jung C, Shin S, Park IK. Pyridoxal phosphate inhibits the group I intron splicing. Mol Cell Biochem. 2005 Dec;280(1-2):17-23
[3] Grin IR, Rieger RA, Zharkov DO. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0463 mL
- 20.2313 mL
- 40.4626 mL
- 5 mM
- 0.8093 mL
- 4.0463 mL
- 8.0925 mL
- 10 mM
- 0.4046 mL
- 2.0231 mL
- 4.0463 mL

技术信息

CAS号

54-47-7

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C8H10NO6P

运输

蓝冰

分子量

247.14

别名

Pyridoxal 5′-phosphate;Pyridoxyl phosphate;MC-1;磷酸吡哆醛

溶解度

DMSO	10.0 mg/mL (40.5 mM)
Ethanol	Insoluble

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磷酸吡哆醛 Catalog No. CSN23400

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