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CAS No.: 10592-13-9

盐酸多西环素 Catalog No. CSN15685

Synonyms: Vibramycin HCl;Doxycycline Hydrochloride;盐酸多西环素

Doxycycline HCl is a broad-spectrum antibiotic used to treat infections caused by bacteria, including pneumonia and other respiratory tract infections, and an MMP inhibitor.

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技术信息

生物活性

描述Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor^[3]. The hydrophilic drug doxycycline hydrochloride, loaded in Tween 80 coated chitosan nanoparticles, can be effectively brain targeted through oral delivery and therefore represents a suitable approach for the treatment of psychotic symptoms^[4]. Doxycycline doses commonly used with inducible expression systems (0.01⁻1 µg/mL) substantially alter cellular metabolism: Mitochondrial protein synthesis was inhibited accompanied by reduced oxygen and increased glucose consumption. Furthermore, doxycycline protected human glioma cells from hypoxia-induced cell death^[5]. The combination of Ningmitai Capsules and doxycycline hydrochloride is more effective than either Ningmitai Capsules or doxycycline hydrochloride used alone in the treatment of Uu (Ureaplasma urealyticum)positive chronic prostatitis^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02564471	Rabies	Phase 4	Recruiting	December 2018	United States, New York ... more >> State University of New York, Upstate Medical University (SUNY-UMU) Recruiting Syracuse, New York, United States, 13210 Contact: Lisa Ware, MS 315-464-4398 warel@upstate.edu Collapse <<
NCT01600625	Meibomian Gland Dysfunction	Not Applicable	Completed	-	Korea, Republic of ... more >> Severance Hospital Seoul, Korea, Republic of, 120-752 Collapse <<
NCT01880515	Skin Rash Lun... more >>g Cancer Collapse <<	Phase 2	Completed	-	Mexico ... more >> Instituto Nacional de Cancerología México, D.F., Mexico city, Mexico, 14080 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0795 mL
- 10.3974 mL
- 20.7948 mL
- 5 mM
- 0.4159 mL
- 2.0795 mL
- 4.1590 mL
- 10 mM
- 0.2079 mL
- 1.0397 mL
- 2.0795 mL

技术信息

CAS号

10592-13-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H25ClN2O8

运输

蓝冰

分子量

480.89

别名

Vibramycin HCl;Doxycycline Hydrochloride;盐酸多西环素;盐酸强力霉素

溶解度

DMSO	115.0 mg/mL (239.1 mM)
Water	45.0 mg/mL (93.6 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02564471	Rabies	Phase 4	Recruiting	December 2018	United States, New York ... more >> State University of New York, Upstate Medical University (SUNY-UMU) Recruiting Syracuse, New York, United States, 13210 Contact: Lisa Ware, MS 315-464-4398 warel@upstate.edu Collapse <<
NCT01600625	Meibomian Gland Dysfunction	Not Applicable	Completed	-	Korea, Republic of ... more >> Severance Hospital Seoul, Korea, Republic of, 120-752 Collapse <<
NCT01880515	Skin Rash Lun... more >>g Cancer Collapse <<	Phase 2	Completed	-	Mexico ... more >> Instituto Nacional de Cancerología México, D.F., Mexico city, Mexico, 14080 Collapse <<
NCT01880515	-	-	Completed	-	-
NCT00531934	-	-	Completed	-	-
NCT00803842	Non Small Cell Lung Cancer	Not Applicable	Withdrawn(Investigator left th... more >>e institution and decided not to continue with the study.) Collapse <<	-	-
NCT00531934	Non-Small Cell Lung Cancer	Phase 2	Completed	-	France ... more >> Antibes, France, 06600 Bordeaux, France, 33076 Bordeaux, France, 33300 Brest, France, 29200 Caen, France, 14076 Chalon Sur Saone, France, 71100 Chartres, France, 28018 Draguignan, France, 83007 GAP, France, 05007 Gleize, France, 69400 Limoges, France, 87042 Metz, France, 57038 Nimes, France, 30900 Paris, France, 75116 Paris, France, 75674 Paris, France, 75679 Perigueux, France, 24000 Perpignan, France, 66000 Pierre Benite, France, 69495 Pontoise, France, 95300 Rennes, France, 35033 Rouen, France, 76000 Tours, France, 37044 Vannes, France, 56017 Collapse <<
NCT02874430	Breast Carcinoma ... more >> Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Uterine Corpus Cancer Uterine Corpus Carcinosarcoma Collapse <<	Phase 2	Recruiting	January 2022	United States, Pennsylvania ... more >> Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Jennifer Johnson, MD, PhD 215-955-8874 Sub-Investigator: Adam Berger, MD Sub-Investigator: Theodore Tsangaris, MD Sub-Investigator: Melissa Lazar, MD Sub-Investigator: Christine Kim, MD Sub-Investigator: Norman Rosenblum, MD, PhD Sub-Investigator: Benjamin Leiby, PhD Sub-Investigator: Madalina Tuluc, MD Sub-Investigator: Joanna Chan, MD Sub-Investigator: Ubaldo Martinez Outschoorn, MD Sub-Investigator: Nicole Simone, MD Collapse <<
NCT03076281	Larynx LIP ... more >> Oral Cavity Pharynx Collapse <<	Phase 2	Recruiting	August 2020	United States, Pennsylvania ... more >> Sidney Kimmel Cancer Center at Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Jennifer Johnson, MD, PhD 215-955-8874 jennifer.johnson@jefferson.edu Collapse <<
NCT03340961	Rosacea	Phase 2	Active, not recruiting	December 30, 2018	Germany ... more >> Site 13 Bad Bentheim, Germany Site 07 Berlin, Germany Site 14 Berlin, Germany Site 09 Bochum, Germany Site 05 Buxtehude, Germany Site 15 Darmstadt, Germany Site 03 Dülmen, Germany Site 08 Leipzig, Germany Site 11 Mahlow, Germany Site 06 Münster, Germany Site 10 Osnabrück, Germany Site 01 Pommelsbrunn, Germany Site 04 Potsdam, Germany Site 02 Wuppertal, Germany Collapse <<

盐酸多西环素 Catalog No. CSN15685

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