生物活性

• 描述Tetracycline (hydrochloride) is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria. The obtained lifetime for pheophytin formed during chlorophyll reaction - with tetracycline hydrochloride was τ = 5.71 ± 0.02 ns. The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll^[3]. Moreover, polyethyleneimine (PEI) modified GO as a tetracycline hydrochloride (TCH) carrier and release platform was constructed (pGO-TCH), pGO-TCH nanostructures exhibit good antibacterial behavior^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD Collapse <<
  NCT00003151	Lymphoma	Phase 2	Completed	-	United Kingdom ... more >> Royal United Hospital Bath, England, United Kingdom, BA1 3NG University Birmingham N.H.S. Trust Birmingham, England, United Kingdom, B15 2TA Royal Free Hospital Hampstead, London, England, United Kingdom, NW3 2QG St. James's Hospital Leeds, England, United Kingdom, LS9 7TF Saint Bartholomew's Hospital London, England, United Kingdom, EC1A 7BE Royal Free Hospital School of Medicine London, England, United Kingdom, NW3 2PF Guy's, King's and St. Thomas' Hospitals Trust London, England, United Kingdom, SE1 7EH Royal Marsden NHS Trust London, England, United Kingdom, SW3 6JJ Hammersmith Hospital London, England, United Kingdom, W12 ONN Middlesex Hospital- Meyerstein Institute London, England, United Kingdom, W1N 8AA Charing Cross Hospital London, England, United Kingdom, W6 8RF Clatterbridge Centre for Oncology NHS Trust Merseyside, England, United Kingdom, L63 4JY Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Mount Vernon Hospital Northwood, England, United Kingdom, HA6 2RN Nottingham City Hospital NHS Trust Nottingham, England, United Kingdom, NG5 1PB Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 7LJ Royal South Hants Hospital Southampton, England, United Kingdom, SO14 0YG Royal Marsden Hospital Sutton, England, United Kingdom, SM2 5PT Aberdeen Royal Infirmary Aberdeen, Scotland, United Kingdom, AB25 2ZN Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 9NQ Beatson Oncology Centre Glasgow, Scotland, United Kingdom, G11 6NT Royal Infirmary Glasgow, Scotland, United Kingdom, G4 0SF Collapse <<
  NCT01279187	Implant	Phase 2	Terminated(Study was terminate... more >>d due to patient complications unrelated to study drugs) Collapse <<	-	United States, Michigan ... more >> Michigan Center for Oral Health Research Ann Arbor, Michigan, United States, 48106 Collapse <<

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• 参考文献

• [1] Buck MA, Cooperman BS. Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9.

  [2] Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents.

  [3] Rydzyński D, Piotrowicz-Cieślak AI, Grajek H, Wasilewski J. Investigation of chlorophyll degradation by tetracycline. Chemosphere. 2019;229:409–417

  [4] Jiang L, Su C, Ye S, et al. Synergistic antibacterial effect of tetracycline hydrochloride loaded functionalized graphene oxide nanostructures. Nanotechnology. 2018;29(50):505102