生物活性

• 靶点	DNA/RNA Synthesis Ki:0.02μM

• 描述Daunorubicin hydrochloride inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
• 细胞研究
• Cell Data

  Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
  african green monkey Vero cells	-	Cytotoxic assay	3 days	Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay, IC50=2.5 μM	21094049
  B16 mouse melanoma cells	-	Cytotoxic assay	-	Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay, EC50=0.16 μM	11020285
  CCRF-CEM (human lymphoblastic leukemic) cells	-	Growth inhibition assay	-	In vitro growth inhibitory activity against CCRF-CEM (human lymphoblastic leukemic) cells, ID50=0.04 μM	6951049

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• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02182596	Acute Myeloid Leukemia	Phase 1 Phase 2	Completed	-	France ... more >> Hopital Avicenne Bobigny, France CH Caen, France, 14033 Hopital Percy Clamart, France, 92141 CHU Creteil, France, 94010 CHU Lille, France, 59037 CH Limoges, France, 87042 Hopital Edouard Herriot Lyon, France CH Meaux, France, 77104 St Antoine Hospital Paris, France, 75012 Hopital Saint-Louis Paris, France CH Roubaix, France, 59100 CHU Rouen, France, 76038 CNLCC Saint-Cloud, France CH Versailles, France IGR Villejuif, France, 94805 Collapse <<
  NCT01074086	AML	Phase 1	Completed	-	France ... more >> Sophie Park Paris, France, 75014 Collapse <<
  NCT03135028	Hematologic Malignancy ... more >> Acute Myeloid Leukemia Collapse <<	Phase 1	Active, not recruiting	December 2018	Japan ... more >> University of Fukui Hospital Fukui, Japan, 910-1193 Kyushu University Hospital Fukuoka, Japan, 812-8582 Tokai University Hospital Kanagawa, Japan, 259-1193 Tohoku University Hospital Miyagi, Japan, 980-8574 NTT Medical Center Tokyo Tokyo, Japan, 141-8625 Kindai University Hospital Ōsaka, Japan, 589-8511 Collapse <<

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• 参考文献

• [1] De Beer EL, Bottone AE, Voest EE. Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: a review. Eur J Pharmacol. 2001 Mar 9;415(1):1-11.

  [2] Bose R, Verheij M, et al.Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 1995 Aug 11;82(3):405-14.