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CAS No.: 961-29-5
Synonyms: 异甘草素;GU17;ISL
Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00193154 | Kidney Cancer | Phase 2 | Completed | - | United States, Louisiana ... more >> Medical Oncology LLC Baton Rouge, Louisiana, United States, 70809 United States, Michigan Grand Rapids Oncology Program Grand Rapids, Michigan, United States, 49503 Collapse << |
NCT03501381 | Renal Cell Carcinoma | Phase 2 | Recruiting | April 2023 | United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD 317-278-7776 rpili@iu.edu Principal Investigator: Roberto Pili, MD United States, Nebraska Nebraska Methodist Hospital Recruiting Omaha, Nebraska, United States, 68114 Contact: Craig Ryan craig.ryan@nmhs.org Principal Investigator: Ralph Hauke, MD Collapse << |
NCT03552380 | Renal Cell Carcinoma | Phase 2 | Recruiting | August 2020 | United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD 317-278-7776 rpili@iu.edu Principal Investigator: Roberto Pili, MD Collapse << |
实验方案
技术信息
CAS号 | 961-29-5 | 储存条件 |
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分子式 | C15H12O4 | 运输 | 蓝冰 | |||||||
分子量 | 256.25 | 别名 | 异甘草素;GU17;ISL;Isoliquiritigen;SJ000286237 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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CHO cells | - | Cytotoxicity assay | - | Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM | 19572738 |
colon 26-L5 cells | - | Cytotoxicity assay | 72 h | Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM | 18440233 |
dog MDCK cells | 20 ug/mL | Function assay | 1 h | Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control | 22743086 |
dog MDCK cells | - | Function assay | 8 h | Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence | 22743086 |
dog MDCK cells | - | Function assay | - | Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay | 22743086 |
Hepa lclc7 cells | - | Cytotoxicity assay | - | Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM | 18076142 |
Hepa lclc7 cells | - | Function assay | - | Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity | 18076142 |
Hepa-1c1c7 cells | - | Function assay | - | Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity | 12762787 |
human T47D cells | - | Function assay | 96 h | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 |
HUVEC | - | Cytotoxicity assay | 48 h | Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM | 25590864 |
J774.1 cells | - | Function assay | 24 h | Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM | 15974608 |
K562 cells | - | Cytotoxicity assay | 48 h | Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM | 25590864 |
KB cells | - | Growth inhibition assay | - | Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM | 9767632 |
MCF7 cells | 25-150 μM | Cytotoxicity assay | 72 h | Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay | 18603336 |
MCF7 cells | - | Function assay | 96 h | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 |
MCF7 cells | - | Function assay | - | Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay | 19928832 |
mouse NIH3T3 cells | - | Function assay | 8 h | Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM | 21112783 |
MT-4 cells | - | Growth inhibition assay | - | Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM | 9767632 |
NCI-H292 cells | - | Function assay | - | Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 |
NCI-H292 cells | - | Function assay | - | Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 |
NCI-H292 cells | - | Function assay | - | Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 |
OE21 cells | - | Cytotoxicity assay | 72 h | Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM | 21696954 |
PC3 cells | - | Cytotoxicity assay | - | Cytotoxicity against human PC3 cells, IC50=46.4 μM | 16441066 |
RBL-1 cells | - | Function assay | - | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM | 8254620 |
U937 cells | 5 ug/ml | Function assay | 24 h | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 21866899 |
U937 cells | 5 ug/ml | Function assay | - | Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control | 21866899 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00193154 | Kidney Cancer | Phase 2 | Completed | - | United States, Louisiana ... more >> Medical Oncology LLC Baton Rouge, Louisiana, United States, 70809 United States, Michigan Grand Rapids Oncology Program Grand Rapids, Michigan, United States, 49503 Collapse << |
NCT03501381 | Renal Cell Carcinoma | Phase 2 | Recruiting | April 2023 | United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD 317-278-7776 rpili@iu.edu Principal Investigator: Roberto Pili, MD United States, Nebraska Nebraska Methodist Hospital Recruiting Omaha, Nebraska, United States, 68114 Contact: Craig Ryan craig.ryan@nmhs.org Principal Investigator: Ralph Hauke, MD Collapse << |
NCT03552380 | Renal Cell Carcinoma | Phase 2 | Recruiting | August 2020 | United States, Indiana ... more >> Indiana Univeristy Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Roberto Pili, MD 317-278-7776 rpili@iu.edu Principal Investigator: Roberto Pili, MD Collapse << |
NCT03737123 | Urothelial Carcinoma | Phase 2 | Not yet recruiting | January 2022 | - |
NCT03557918 | Urothelial Carcinoma | Phase 2 | Not yet recruiting | July 2020 | - |
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