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CAS No.: 1290541-46-6
Synonyms: B02;RAD51 inhibitor B02;RAD51-IN-02
B02 is a RAD51 inhibitor with IC50 of 27.4 μM for human RAD51.
生物活性
实验方案
技术信息
CAS号 | 1290541-46-6 | 储存条件 |
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分子式 | C22H17N3O | 运输 | 蓝冰 | |||||
分子量 | 339.39 | 别名 | B02;RAD51 inhibitor B02;RAD51-IN-02 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HEK cells | 25 uM | Function assay | - | Inhibition of DNA binding to human RAD51 in irradiated HEK cells assessed as reduction in RAD51 foci formation at 25 uM by fluorescence microscopy relative to untreated control, | 22380680 |
MEF cells | 5 uM | Function assay | 1 h | Inhibition of RAD51 in Tp53-/- MEF cells assessed as potentiation of 32 uM cisplatin-induced cytotoxicity at 5 uM incubated for 1 hr by clonogenic survival assay relative to untreated control | 22380680 |
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