|(E)-N'-((2-羟基萘-1-基)亚甲基)异烟酰肼|CsnPharm

CAS No.: 329183-01-9

(E)-N'-((2-Hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Catalog No. CSN21279

Synonyms: NSC51355;NCI 51355

AS8351 is a selective inhibitor of histone demethylase KDM5B (JARID1B) via competing for the chelated iron KDM5B needs and it can act as an iron chelator.

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技术信息

生物活性

描述AS8351 works as a KDM5B inhibitor and efficiently induces cardiac reprogramming through combination with compound CHIR99021, BIX01294, AS8351, SC1, Y27632 and OAC2. This reprogramming induction effect of AS8351 may due to its targeting on KDM5B, which may facilitate this process and sustain the active chromatin marks (i.e., H3K4 methylation) at specific genomic loci^[2].
作用机制AS8351 affects epigenetic modifications by competing with α-ketoglutarate for chelating iron/Fe(II) in certain epigenetic enzymes, such as the JmjC-domain-containing his-tone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.^[2]
参考文献

[1] Cao N, Huang Y, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.
[2] Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20. doi: 10.1126/science.aaf1502. Epub 2016 Apr 28. PMID: 27127239.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4328 mL
- 17.1642 mL
- 34.3284 mL
- 5 mM
- 0.6866 mL
- 3.4328 mL
- 6.8657 mL
- 10 mM
- 0.3433 mL
- 1.7164 mL
- 3.4328 mL

技术信息

CAS号

329183-01-9

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H13N3O2

运输

蓝冰

分子量

291.30

别名

NSC51355;NCI 51355

溶解度

DMSO	50.0 mg/mL (171.6 mM)

动物实验配方

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(E)-N'-((2-Hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Catalog No. CSN21279

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