CAS No.: 937270-47-8
(E/Z)-Zotiraciclib/SB1317游离态 Catalog No. CSN18607
Synonyms: (E/Z)-TG02;(E/Z)-SB1317;Zotiraciclib
SB-1317 is a small molecule potent CDK2/JAK2/FLT3 inhibitor with IC50s of 13/73/56 nM respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Pasha MK, Jayaraman R, et al. Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.
- [2] William AD, Lee AC, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26- tetraazatetracyclo[19.3.1.1(2,6).1(8,12)] heptacosa1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012 Jan 12;55(1):169-96.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 937270-47-8 | 储存条件 |
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| 分子式 | C23H24N4O | 运输 | 蓝冰 | |
| 分子量 | 372.46 | 别名 | (E/Z)-TG02;(E/Z)-SB1317;Zotiraciclib;SB-1317;Ex-45;Zotiraciclib free base |
