|(R)-(6-甲氧基吡啶-4-基)((1S,2S,4S,5R)-5-乙烯基奎宁环-2-基)甲醇盐酸盐二水合物|CsnPharm

CAS No.: 6119-47-7

奎宁盐酸盐二水合物 Catalog No. CSN11819

Synonyms: Qualaquin;奎宁盐酸盐二水合物

Quinine HCl, a natural white crystalline alkaloid, is a K+ channel blocker with antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties.

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技术信息

生物活性

描述Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 +/- 25 hours (mean +/- 1 S.D.) after treatment was begun and then declining^[3]. All field isolates exhibited higher IC50 values of CQ (chloroquine diphosphate), quinine hydrochloride dihydrate and DHA (dihydro-artemisinin) compared to reference strains. The resistance index of field isolates with respect to 3D7 ranged between 260.55 and 403.78 to CQ, 39.83 and 46.42 to quinine, and 2.98 and 4.16 to DHA^[4]. In a multilevel Poisson regression model adjusted for sex, age, ADL(activities of daily living), smoking status, drinking status, number of medications used, use of medication for hypertension and diabetes and flow rate of saliva, subjects with low sensitivity (>0·003% quinine hydrochloride dihydrate) to bitter taste had a significant 1·70 times higher prevalence ratio (95% confident interval 1·04-2·80) for underweight compared with those with high sensitivity (0·0001% quinine hydrochloride dihydrate) ^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01289561	Alcohol or Other Drugs Effects	Phase 1	Completed	-	United States, Maryland ... more >> Behavioral Pharmacology Research Unit Baltimore, Maryland, United States, 21224 Collapse <<
NCT01289561	Alcohol or Other Drugs Effects	Phase 1	Completed	-	United States, Maryland ... more >> Behavioral Pharmacology Research Unit Baltimore, Maryland, United States, 21224 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5195 mL
- 12.5974 mL
- 25.1947 mL
- 5 mM
- 0.5039 mL
- 2.5195 mL
- 5.0389 mL
- 10 mM
- 0.2519 mL
- 1.2597 mL
- 2.5195 mL

技术信息

CAS号

6119-47-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H29ClN2O4

运输

蓝冰

分子量

396.91

别名

Qualaquin;奎宁盐酸盐二水合物

溶解度

DMSO	625.0 mg/mL (1574.7 mM) warming
Water	50.0 mg/mL (126.0 mM) warming

动物实验配方

0.5% CMC-Na

30 mg/mL

suspension

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奎宁盐酸盐二水合物 Catalog No. CSN11819