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CAS No.: 116649-85-5

雷马曲班 Catalog No. CSN19400

Synonyms: BAY u3405;Bay u 3406;EN 137774

Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.

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技术信息

生物活性

描述Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding. Ramatroban also inhibits human CYP isoform CYP2C9 with an IC50 of 15 μM^[3]. Ramatroban, a small-molecule antagonist of DP2 and TP receptors, reverses viremia-associated proinflammatory, immunosuppressive5 and prothrombotic processes which are similar to those induced by SARS-Cov-2^[4]. Ramatroban, a dual CRTH2/thromboxane-like prostanoid receptor antagonist, markedly inhibited Th2 cytokine production induced by PGD2, while the selective thromboxane-like prostanoid receptor antagonist SQ29548 was without effect^[5]. Ramatroban significantly alleviated silica-induced pulmonary inflammation, fibrosis, and cardiopulmonary dysfunction compared with the control group^[6]. Ramatroban similarly inhibited asthma pathology in vivo by reducing peribronchial eosinophilia and mucus cell hyperplasia^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00311051	Asthma	Phase 2 Phase 3	Withdrawn	-	Germany ... more >> Research Center Borstel Borstel, Germany, 23845 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4012 mL
- 12.0058 mL
- 24.0116 mL
- 5 mM
- 0.4802 mL
- 2.4012 mL
- 4.8023 mL
- 10 mM
- 0.2401 mL
- 1.2006 mL
- 2.4012 mL

技术信息

CAS号

116649-85-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H21FN2O4S

运输

蓝冰

分子量

416.47

别名

BAY u3405;Bay u 3406;EN 137774;雷马曲班

溶解度

DMSO	138.0 mg/mL (331.4 mM)
Water	insoluble

动物实验配方

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