|(R)-5,8-二羟基-2-(1-羟基-4-甲基戊-3-烯-1-基)萘-1,4-二酮|CsnPharm

CAS No.: 517-89-5

紫草素 Catalog No. CSN12365

Synonyms: 紫草素;C.I. 75535;Isoarnebin 4

Shikonin is an inhibitor of TMEM16A chloride channel with IC50 of 6.5 μM, it's a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc..

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Shikonin is the major bioactive chemical component of Lithospermum erythrorhizon (Purple Cromwell) roots. It shows anticancer activity both in vitro and in vivo. At low concentration, shikonin induced apoptosis in various kinds of cell lines of different origins, including M10 (Mammary epithelial cells), EC109, EC9706 (Esophageal cancer,Esophageal epithelial cells), HCT116, SW620 (Colon cancer), A549 (Lung adenocarcinoma), AGS (Gastric cancer), 8505C8305C, FTC133, BCPAP, TPC1C643IHH4, K (Thyroid cancer) and Htori (Immortalized thyroid epithelial cells), etc.. However, at high concentrations shikonin induced necroptosis in various cancer cell lines. The mode of action of shikonin is associated with cell cycle, glycolysis, metastasis, DNA damage, inflammation, angiogenesis, epigenetics, autophagy or ferroxitosis. In vivo studies showed that shikonin exhibited anti-tumor eﬀects through chemoprevention, cell death or other mechanisms in xenograft, carcinogen-induced, orthotopic or allograft cancer models. Shikonin is also used as a PKM2 inhibitor. Inhibition of PKM2 by shikonin re-sensitized the cisplatin resistant T24 cells and killed the T24 cisplatin resistant cells by inducing necroptosis at concentration of 0.4μM. Recent study found that shikonin showed inhibition effect on 2019-nCoV.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
8-MG-BA cell	-	Growth inhibition assay	-	Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50=85.56 nM	SANGER
A101D cell	-	Growth inhibition assay	-	Inhibition of human A101D cell growth in a cell viability assay, IC50=0.712 nM	SANGER
A204 cell	-	Growth inhibition assay	-	Inhibition of human A204 cell growth in a cell viability assay, IC50=0.12654 μM	SANGER

更多
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01968928	-	-	Unknown	December 2016	Taiwan ... more >> Department of Urology, National Taiwan University Hospital Not yet recruiting Taipei, Taiwan, 10002 Contact: Kuo-How Huang, M.D.,Ph.D. 886-2-23123456 ext 65952 khhuang123@ntu.edu.tw Principal Investigator: Kuo-How Huang, M.D.,Ph.D. Collapse <<
NCT01287468	-	-	Unknown	December 2014	Taiwan ... more >> Taipei Medical University - WanFang Hospital Taipei, Taiwan Collapse <<

参考文献

[1] Fu D, Shang X, Ni Z, Shi G. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med. 2016 Oct;12(4):2735-2740.
[2] Jiang Y, Yu B, et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4686 mL
- 17.3430 mL
- 34.6861 mL
- 5 mM
- 0.6937 mL
- 3.4686 mL
- 6.9372 mL
- 10 mM
- 0.3469 mL
- 1.7343 mL
- 3.4686 mL

技术信息

CAS号

517-89-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H16O5

运输

蓝冰

分子量

288.30

别名

紫草素;C.I. 75535;Isoarnebin 4

溶解度

DMSO	56.0 mg/mL (194.2 mM)
Water	Insoluble
Ethanol	22.0 mg/mL (76.3 mM)

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water

3 mg/mL

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

8-MG-BA cell	-	Growth inhibition assay	-	Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50=85.56 nM	SANGER
A101D cell	-	Growth inhibition assay	-	Inhibition of human A101D cell growth in a cell viability assay, IC50=0.712 nM	SANGER
A204 cell	-	Growth inhibition assay	-	Inhibition of human A204 cell growth in a cell viability assay, IC50=0.12654 μM	SANGER
A253 cell	-	Growth inhibition assay	-	Inhibition of human A253 cell growth in a cell viability assay, IC50=7.49 nM	SANGER
A427 cell	-	Growth inhibition assay	-	Inhibition of human A427 cell growth in a cell viability assay, IC50=17.99 nM	SANGER
A431 cell	-	Growth inhibition assay	-	Inhibition of human A431 cell growth in a cell viability assay, IC50=0.10697 μM	SANGER
A498 cell	-	Growth inhibition assay	-	Inhibition of human A498 cell growth in a cell viability assay, IC50=81.9 nM	SANGER
ACHN cell	-	Growth inhibition assay	-	Inhibition of human ACHN cell growth in a cell viability assay, IC50=0.14638 μM	SANGER
AM-38 cell	-	Growth inhibition assay	-	Inhibition of human AM-38 cell growth in a cell viability assay, IC50=96.31 nM	SANGER
AN3-CA cell	-	Growth inhibition assay	-	Inhibition of human AN3-CA cell growth in a cell viability assay, IC50=79.65 nM	SANGER
BT-474 cell	-	Growth inhibition assay	-	Inhibition of human BT-474 cell growth in a cell viability assay, IC50=0.20836 μM	SANGER
CA46 cell	-	Growth inhibition assay	-	Inhibition of human CA46 cell growth in a cell viability assay, IC50=0.19185 μM	SANGER
CAL-51 cell	-	Growth inhibition assay	-	Inhibition of human CAL-51 cell growth in a cell viability assay, IC50=20.85 nM	SANGER
CAL-85-1 cell	-	Growth inhibition assay	-	Inhibition of human CAL-85-1 cell growth in a cell viability assay, IC50=0.16073 μM	SANGER
CHL-1 cell	-	Growth inhibition assay	-	Inhibition of human CHL-1 cell growth in a cell viability assay, IC50=0.1678 μM	SANGER
COLO-679 cell	-	Growth inhibition assay	-	Inhibition of human COLO-679 cell growth in a cell viability assay, IC50=0.18401 μM	SANGER
COR-L105 cell	-	Growth inhibition assay	-	Inhibition of human COR-L105 cell growth in a cell viability assay, IC50=0.23034 μM	SANGER
Daoy cell	-	Growth inhibition assay	-	Inhibition of human Daoy cell growth in a cell viability assay, IC50=0.15877 μM	SANGER
DEL cell	-	Growth inhibition assay	-	Inhibition of human DEL cell growth in a cell viability assay, IC50=0.15381 μM	SANGER
DU-145 cell	-	Growth inhibition assay	-	Inhibition of human DU-145 cell growth in a cell viability assay, IC50=0.19309 μM	SANGER
DU-4475 cell	-	Growth inhibition assay	-	Inhibition of human DU-4475 cell growth in a cell viability assay, IC50=0.17984 μM	SANGER
EFM-19 cell	-	Growth inhibition assay	-	Inhibition of human EFM-19 cell growth in a cell viability assay, IC50=0.2121 μM	SANGER
G-401 cell	-	Growth inhibition assay	-	Inhibition of human G-401 cell growth in a cell viability assay, IC50=0.23492 μM	SANGER
GCIY cell	-	Growth inhibition assay	-	Inhibition of human GCIY cell growth in a cell viability assay, IC50=35.98 nM	SANGER
GR-ST cell	-	Growth inhibition assay	-	Inhibition of human GR-ST cell growth in a cell viability assay, IC50=0.10218 μM	SANGER
HAL-01 cell	-	Growth inhibition assay	-	Inhibition of human HAL-01 cell growth in a cell viability assay, IC50=0.19573 μM	SANGER
HCT116 cells	-	Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=0.23 μM	17949858
HCT15 cells	-	Function assay	24 h	Antitumor activity against human HCT15 cells after 24 hrs by MTT assay, IC50=7.3 μM	21620530
HepG2 cell	-	Cytotoxicity assay	24 h	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=0.24 μM	17949858
HGC-27 cell	-	Growth inhibition assay	-	Inhibition of human HGC-27 cell growth in a cell viability assay, IC50=0.22834 μM	SANGER
HL60 cells	-	Cytotoxicity assay	-	Cytotoxicity against human HL60 cells by MTT assay, IC50=0.44 μM	19111464
HLE cell	-	Growth inhibition assay	-	Inhibition of human HLE cell growth in a cell viability assay, IC50=88.31 nM	SANGER
HMV-II cell	-	Growth inhibition assay	-	Inhibition of human HMV-II cell growth in a cell viability assay, IC50=56.4 nM	SANGER
HOS cell	-	Growth inhibition assay	-	Inhibition of human HOS cell growth in a cell viability assay, IC50=0.18608 μM	SANGER
HSC-2 cell	-	Growth inhibition assay	-	Inhibition of human HSC-2 cell growth in a cell viability assay, IC50=0.22318 μM	SANGER
IGR-1 cell	-	Growth inhibition assay	-	Inhibition of human IGR-1 cell growth in a cell viability assay, IC50=0.15398 μM	SANGER
IGROV-1 cell	-	Growth inhibition assay	-	Inhibition of human IGROV-1 cell growth in a cell viability assay, IC50=55.61 nM	SANGER
IST-SL2 cell	-	Growth inhibition assay	-	Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50=0.20014 μM	SANGER
J82 cell	-	Growth inhibition assay	-	Inhibition of human J82 cell growth in a cell viability assay, IC50=0.14255 μM	SANGER
KASUMI-1 cell	-	Growth inhibition assay	-	Inhibition of human KASUMI-1 cell growth in a cell viability assay, IC50=0.12371 μM	SANGER
KS-1 cell	-	Growth inhibition assay	-	Inhibition of human KS-1 cell growth in a cell viability assay, IC50=41.5 nM	SANGER
KU812 cell	-	Growth inhibition assay	-	Inhibition of human KU812 cell growth in a cell viability assay, IC50=8.31 nM	SANGER
KYSE-270 cell	-	Growth inhibition assay	-	Inhibition of human KYSE-270 cell growth in a cell viability assay, IC50=0.21692 μM	SANGER
KYSE-450 cell	-	Growth inhibition assay	-	Inhibition of human KYSE-450 cell growth in a cell viability assay, IC50=0.13815 μM	SANGER
LB647-SCLC cell	-	Growth inhibition assay	-	Inhibition of human LB647-SCLC cell growth in a cell viability assay, IC50=0.23278 μM	SANGER
M059J cell	-	Growth inhibition assay	-	Inhibition of human M059J cell growth in a cell viability assay, IC50=0.13419 μM	SANGER
MCF7 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=1.45 μM	20403646
MDA-MB-231 cells	-	Function assay	24 h	Antitumor activity against human MDA-MB-231 cells after 24 hrs by MTT assay, IC50=6.6 μM	21620530
MEL-HO cell	-	Growth inhibition assay	-	Inhibition of human MEL-HO cell growth in a cell viability assay, IC50=0.14882 μM	SANGER
MES-SA cell	-	Growth inhibition assay	-	Inhibition of human MES-SA cell growth in a cell viability assay, IC50=41.32 nM	SANGER
MKN1 cell	-	Growth inhibition assay	-	Inhibition of human MKN1 cell growth in a cell viability assay, IC50=0.23576 μM	SANGER
mouse L929 cells	-	Cytotoxicity assay	24 h	Cytotoxicity against mouse L929 cells after 24 hrs by MTT assay, IC50=3.2 μM	21620530
MRK-nu-1 cell	-	Growth inhibition assay	-	Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50=0.10193 μM	SANGER
MZ1-PC cell	-	Growth inhibition assay	-	Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50=19.28 nM	SANGER
MZ7-mel cell	-	Growth inhibition assay	-	Inhibition of human MZ7-mel cell growth in a cell viability assay, IC50=0.11372 μM	SANGER
NALM-6 cell	-	Growth inhibition assay	-	Inhibition of human NALM-6 cell growth in a cell viability assay, IC50=2.8 nM	SANGER
NB69 cell	-	Growth inhibition assay	-	Inhibition of human NB69 cell growth in a cell viability assay, IC50=0.21273 μM	SANGER
NCI-H1963 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1963 cell growth in a cell viability assay, IC50=0.10011 μM	SANGER
NCI-H2009 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50=20.54 nM	SANGER
NCI-H2052 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H2052 cell growth in a cell viability assay, IC50=61.13 nM	SANGER
NCI-H2342 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H2342 cell growth in a cell viability assay, IC50=0.13445 μM	SANGER
NKM-1 cell	-	Growth inhibition assay	-	Inhibition of human NKM-1 cell growth in a cell viability assay, IC50=0.1012 μM	SANGER
NTERA-S-cl-D1 cell	-	Growth inhibition assay	-	Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50=0.14357 μM	SANGER
P30-OHK cell	-	Growth inhibition assay	-	Inhibition of human P30-OHK cell growth in a cell viability assay, IC50=0.22048 μM	SANGER
PA-1 cell	-	Growth inhibition assay	-	Inhibition of human PA-1 cell growth in a cell viability assay, IC50=0.20128 μM	SANGER
PANC-03-27 cell	-	Growth inhibition assay	-	Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50=0.1674 μM	SANGER
QIMR-WIL cell	-	Growth inhibition assay	-	Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50=0.18189 μM	SANGER
REH cell	-	Growth inhibition assay	-	Inhibition of human REH cell growth in a cell viability assay, IC50=0.14696 μM	SANGER
RPMI-7951 cell	-	Growth inhibition assay	-	Inhibition of human RPMI-7951 cell growth in a cell viability assay, IC50=0.15609μM	SANGER
RT-112 cell	-	Growth inhibition assay	-	Inhibition of human RT-112 cell growth in a cell viability assay, IC50=70.37 nM	SANGER
SBC-5 cell	-	Growth inhibition assay	-	Inhibition of human SBC-5 cell growth in a cell viability assay, IC50=0.21546 μM	SANGER
SCC-9 cell	-	Growth inhibition assay	-	Inhibition of human SCC-9 cell growth in a cell viability assay, IC50=0.19675 μM	SANGER
SIG-M5 cell	-	Growth inhibition assay	-	Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50=0.16986 μM	SANGER
SK-LMS-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50=0.10841 μM	SANGER
SK-PN-DW cell	-	Growth inhibition assay	-	Inhibition of human SK-PN-DW cell growth in a cell viability assay, IC50=36.55 nM	SANGER
SK-UT-1 cell growth	-	Growth inhibition assay	-	Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50=7.44 nM	SANGER
SNU-423 cell	-	Growth inhibition assay	-	Inhibition of human SNU-423 cell growth in a cell viability assay, IC50=0.16307 μM	SANGER
SR cell	-	Growth inhibition assay	-	Inhibition of human SR cell growth in a cell viability assay, IC50=0.14073 μM	SANGER
ST486 cell	-	Growth inhibition assay	-	Inhibition of human ST486 cell growth in a cell viability assay, IC50=6.18 nM	SANGER
SW1710 cell	-	Growth inhibition assay	-	Inhibition of human SW1710 cell growth in a cell viability assay, IC50=2.91 nM	SANGER
SW982 cell	-	Growth inhibition assay	-	Inhibition of human SW982 cell growth in a cell viability assay, IC50=60.23 nM	SANGER
T47D cell	-	Growth inhibition assay	-	Inhibition of human T47D cell growth in a cell viability assay, IC50=0.22306 μM	SANGER
TE-441-T cell	-	Growth inhibition assay	-	Inhibition of human TE-441-T cell growth in a cell viability assay, IC50=2.24 nM	SANGER
YKG-1 cell	-	Growth inhibition assay	-	Inhibition of human YKG-1 cell growth in a cell viability assay, IC50=0.22891 μM	SANGER

紫草素 Catalog No. CSN12365

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