CAS No.: 668270-12-0
利拉利汀 Catalog No. CSN12323
Synonyms: BI 1356;利格列汀
Linagliptin, a purine and quinazoline derivative, can inhibit DPP-4 with IC50 of 1 nM. It functions as an incretin and is used as a hypoglycemic agents in the treatment of type 2 diabetes mellitus.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 DPP4
IC50:1nM- 描述
- 细胞研究
- Cell Data
- 更多
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02183376 Hepatic Insufficiency Phase 1 Completed - - NCT01778049 Diabetes Mellitus, Type 2 Phase 3 Completed - - NCT02183532 Healthy Phase 1 Completed - - - 更多
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 668270-12-0 | 储存条件 |
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| 分子式 | C25H28N8O2 | 运输 | 蓝冰 | |||||||||||
| 分子量 | 472.54 | 别名 | BI 1356;利格列汀 | |||||||||||
| 溶解度 |
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动物实验配方 |
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| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| CHO cells | - | Function assay | - | Displacement of [N-methyl-3H]scopolamine from human recombinant muscarinic M1 receptor expressed in CHO cells, IC50=0.295 μM | 18052023 |
| HEK293 cells | - | Function assay | - | Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition, IC50=0.37 μM | 24900696 |
| human Caco-2 cells | - | Function assay | - | Inhibition of DPP4 in human Caco-2 cells after 1 hr, IC50=1 nM | 18485703 |
| pig LLC-PK1 cells | 100 μM | Function assay | - | Maximal inhibition of human P-glycoprotein expressed in pig LLC-PK1 cells assessed as reduction of [3H]digoxin substrate transport at 100 uM by liquid scintillation counting | 23073734 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT02183376 | Hepatic Insufficiency | Phase 1 | Completed | - | - |
| NCT01778049 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT02183532 | Healthy | Phase 1 | Completed | - | - |
| NCT01778049 | - | - | Completed | - | - |
| NCT00819091 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01703286 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | Germany ... more >> 1218.105.001 Boehringer Ingelheim Investigational Site Neuss, Germany Collapse << |
| NCT00819091 | - | - | Completed | - | - |
| NCT02173639 | Healthy | Phase 1 | Completed | - | - |
| NCT01703286 | - | - | Completed | - | - |
| NCT01087502 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT02173652 | Healthy | Phase 1 | Completed | - | - |
| NCT01087502 | - | - | Completed | - | - |
| NCT01734785 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01708902 | - | - | Completed | - | - |
| NCT02821910 | Healthy | Phase 1 | Completed | - | Germany ... more >> Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT02183428 | Healthy | Phase 1 | Completed | - | - |
| NCT01708902 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01215097 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | China ... more >> 1218.65.86007 Boehringer Ingelheim Investigational Site Beijing, China 1218.65.86011 Boehringer Ingelheim Investigational Site Chongqing, China 1218.65.86008 Boehringer Ingelheim Investigational Site Dalian, China 1218.65.86010 Boehringer Ingelheim Investigational Site Fuzhou, China 1218.65.86014 Boehringer Ingelheim Investigational Site Hangzhou, China 1218.65.86005 Boehringer Ingelheim Investigational Site Hefei, China 1218.65.86006 Boehringer Ingelheim Investigational Site Hefei, China 1218.65.86012 Boehringer Ingelheim Investigational Site Nanjing, China 1218.65.86001 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86002 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86003 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86004 Boehringer Ingelheim Investigational Site Suzhou, China 1218.65.86015 Boehringer Ingelheim Investigational Site Wenzhou, China 1218.65.86009 Boehringer Ingelheim Investigational Site Wuhan, China 1218.65.86013 Boehringer Ingelheim Investigational Site Yangzhou, China Malaysia 1218.65.60002 Boehringer Ingelheim Investigational Site Johor Bahru,, Malaysia 1218.65.60001 Boehringer Ingelheim Investigational Site Kelantan, Malaysia Philippines 1218.65.63001 Boehringer Ingelheim Investigational Site Marikina, Philippines 1218.65.63002 Boehringer Ingelheim Investigational Site San Juan, Philippines Collapse << |
| NCT01215097 | - | - | Completed | - | - |
| NCT01734785 | - | - | Completed | - | - |
| NCT00800683 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00621140 | - | - | Completed | - | - |
| NCT02183493 | Healthy | Phase 1 | Completed | - | - |
| NCT02191228 | Renal Insufficiency | Phase 1 | Completed | - | - |
| NCT00800683 | - | - | Completed | - | - |
| NCT02221414 | Healthy | Phase 1 | Completed | - | - |
| NCT02183441 | Healthy | Phase 1 | Completed | - | - |
| NCT00621140 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT02489968 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT03433248 | Type2 Diabetes | Phase 4 | Recruiting | December 1, 2020 | Netherlands ... more >> VU University Medical Center Recruiting Amsterdam, Noord-Holland, Netherlands, 1081HV Contact: Michaël JB van Baar, MD +31 20 444 4709 m.vanbaar@vumc.nl Contact: Daniël H van Raalte, MD PhD +31 20 444 0534 d.vanraalte@vumc.nl Principal Investigator: Mark HH Kramer, MD PhD Principal Investigator: Daniël H van Raalte, MD PhD Collapse << |
| NCT02221401 | Healthy | Phase 1 | Completed | - | - |
| NCT02489968 | - | - | Completed | - | - |
| NCT01438814 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT01947153 | - | - | Completed | - | - |
| NCT02220647 | Healthy | Phase 1 | Completed | - | - |
| NCT01897532 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT01438814 | - | - | Completed | - | - |
| NCT02897349 | Diabetes Mellitus, Type 2 | Phase 3 | Active, not recruiting | January 30, 2019 | China ... more >> China-Japan Friendship Hospital Beijing, China, 100029 Beijing Tongren Hospital Beijing, China, 100730 The General Hospital of Chinese People's Armed Police Forces Beijing, China, 100854 First Hospital of Jilin University Changchun, China, 130021 Fuzhou General Hospital of Nanjing Militray Command Fuzhou, China, 350025 Third Affiliated Hospital of Guangzhou Medical University Guangzhou, China, 510150 The Affiliated Hospital of Guizhou Medical University Guiyang, China, 550004 Hangzhou Second People's Hospital Hangzhou, China, 310015 General Hospital of Jinan Military Area Jinan, China, 250000 Nanjing First Hospital Nanjing, China, 210006 The affiliated hospital of medicalcollege qingdao university Qingdao, China, 266005 Centre Hospital of Putuo District, Shanghai Shanghai, China, 200062 Shanghai Tenth People's Hospital Shanghai, China, 200072 Yangpu Hospital, Tongji University Shanghai, China, 200090 Second Hospital Affiliated to Shantou Medical University Shantou, China, 515041 Shengjing Hospital of China Medical University Shengyang, China, 110072 Siping Central People's Hospital Siping, China, 136000 The First Affiliated Hospital of Soochow University Suzhou, China, 215006 Nankai University Affiliated Hospital Tianjin, China, 300000 The 2nd Hospital of Tianjin Medical University Tianjin, China, 300000 Tianjin Medical University General Hospital Tianjin, China, 30052 Renmin Hospital of Wuhan University Wuhan, China, 430060 First Affiliated Hospital of Xiamen University Xiamen, China, 361003 the first people hospital of Yue Yang Yueyang, China, 414000 Affiliated Hospital of Jiangsu University Zhenjiang, China, 212013 Collapse << |
| NCT01947153 | Healthy | Phase 1 | Completed | - | Russian Federation ... more >> 1288.21.1 Boehringer Ingelheim Investigational Site St. Petersburg, Russian Federation Collapse << |
| NCT02172222 | Healthy | Phase 1 | Completed | - | - |
| NCT01194830 | - | - | Completed | - | - |
| NCT01194830 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01903356 | - | - | Completed | - | Korea, Republic of ... more >> One or multiple Investigational sites, Korea, Republic of Collapse << |
| NCT00602472 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT02183636 | Healthy | Phase 1 | Completed | - | - |
| NCT01342484 | - | - | Completed | - | - |
| NCT00602472 | - | - | Completed | - | - |
| NCT01969084 | Type II Diabetes Mellitus | Phase 4 | Completed | - | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01969084 | - | - | Completed | - | - |
| NCT01512979 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT01888796 | Diabetes Mellitus Type 2 (T2DM... more >>) Left Ventricular Diastolic Dysfunction Collapse << | Phase 3 | Terminated(bad recruitment of ... more >>suitable participants, just 8 patients in one year) Collapse << | - | Germany ... more >> Department of Internal Medicine I, University Hospital Aachen, Germany, 52074 Collapse << |
| NCT01342484 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | United States, Texas ... more >> 1218.56.01006 Boehringer Ingelheim Investigational Site San Antonio, Texas, United States United States, Virginia 1218.56.01004 Boehringer Ingelheim Investigational Site Norfolk, Virginia, United States Canada, Quebec 1218.56.11001 Boehringer Ingelheim Investigational Site Montreal, Quebec, Canada France 1218.56.33003 Boehringer Ingelheim Investigational Site Fort de France cedex, France 1218.56.33006 Boehringer Ingelheim Investigational Site Rouen, France Guatemala 1218.56.50202 Boehringer Ingelheim Investigational Site Guatemala, Guatemala 1218.56.50203 Boehringer Ingelheim Investigational Site Guatemala, Guatemala Italy 1218.56.39005 Boehringer Ingelheim Investigational Site Firenze, Italy Korea, Republic of 1218.56.82005 Boehringer Ingelheim Investigational Site Busan, Korea, Republic of 1218.56.82001 Boehringer Ingelheim Investigational Site Seoul, Korea, Republic of 1218.56.82002 Boehringer Ingelheim Investigational Site Seoul, Korea, Republic of 1218.56.82003 Boehringer Ingelheim Investigational Site Suwon, Korea, Republic of Mexico 1218.56.52008 Boehringer Ingelheim Investigational Site Chihuahua, Mexico 1218.56.52002 Boehringer Ingelheim Investigational Site Guadalajara, Mexico 1218.56.52001 Boehringer Ingelheim Investigational Site León, Mexico 1218.56.52003 Boehringer Ingelheim Investigational Site Monterrey, Mexico 1218.56.52004 Boehringer Ingelheim Investigational Site Oaxaca, Mexico Poland 1218.56.48002 Boehringer Ingelheim Investigational Site Gdansk, Poland 1218.56.48001 Boehringer Ingelheim Investigational Site Gliwice, Poland 1218.56.48004 Boehringer Ingelheim Investigational Site Warszawa, Poland 1218.56.48003 Boehringer Ingelheim Investigational Site Wroclaw, Poland Russian Federation 1218.56.70001 Boehringer Ingelheim Investigational Site Moscow, Russian Federation 1218.56.70003 Boehringer Ingelheim Investigational Site Saratov, Russian Federation 1218.56.70004 Boehringer Ingelheim Investigational Site Ufa, Russian Federation 1218.56.70006 Boehringer Ingelheim Investigational Site Yekaterinburg, Russian Federation Collapse << |
| NCT01512979 | - | - | Completed | - | - |
| NCT01581931 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1288.20.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT03259490 | Healthy | Phase 1 | Completed | - | Germany ... more >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Collapse << |
| NCT01581931 | - | - | Completed | - | - |
| NCT01012037 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | - |
| NCT01243424 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01012037 | - | - | Completed | - | - |
| NCT01276327 | - | - | Completed | - | - |
| NCT01792518 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01792518 | - | - | Completed | - | - |
| NCT00915772 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00601250 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00601250 | - | - | Completed | - | - |
| NCT03642184 | New Onset Diabetes After Trans... more >>plant Kidney Transplant; Complications Collapse << | Phase 4 | Recruiting | December 31, 2020 | China, Shanghai ... more >> Department of nephrology, endocrinology and kidney transplantation , Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine Recruiting Shanghai, Shanghai, China, 200127 Contact: Shan Mou, Dr. +8613918221242 shan_mou@126.com Collapse << |
| NCT03629054 | Healthy | Phase 1 | Completed | - | Germany ... more >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Collapse << |
| NCT00915772 | - | - | Completed | - | - |
| NCT01383356 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | Canada, Ontario ... more >> 1288.19.1 Boehringer Ingelheim Investigational Site Toronto, Ontario, Canada Collapse << |
| NCT01383356 | - | - | Completed | - | - |
| NCT01276327 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1264.14.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT01547104 | Diabetes Mellitus Type 2 | Phase 4 | Unknown | October 2012 | Germany ... more >> ikfe GmbH Recruiting Mainz, Rhineland-Palatinate, Germany, 55116 Contact: Thomas Forst, MD, PhD + 49 6131 57636 ext 16 ThomasF@ikfe.de Contact: Daniela Sachsenheimer, MD + 49 6131 57636 ext 46 DanielaS@ikfe.de Sub-Investigator: Daniela Sachsenheimer, MD Sub-Investigator: Stephanie Helleberg, MD Sub-Investigator: Stefan Diessel Sub-Investigator: Michael Mitry, MD Collapse << |
| NCT00954447 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01845077 | Healthy | Phase 1 | Completed | - | United States, Texas ... more >> 1288.8.1 Boehringer Ingelheim Investigational Site Austin, Texas, United States Collapse << |
| NCT01707147 | - | - | Completed | - | Korea, Republic of ... more >> Multiple Locations, Korea, Republic of Collapse << |
| NCT01189201 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1275.3.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT01189201 | - | - | Completed | - | - |
| NCT00996658 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00996658 | - | - | Completed | - | - |
| NCT02453555 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... more >> 1275.19.81519 Boehringer Ingelheim Investigational Site Aichi, Nagoya, Japan 1275.19.81536 Boehringer Ingelheim Investigational Site Chiba, Kashiwa, Japan 1275.19.81530 Boehringer Ingelheim Investigational Site Fukuoka, Fukuoka, Japan 1275.19.81529 Boehringer Ingelheim Investigational Site Fukuoka, Itoshima, Japan 1275.19.81531 Boehringer Ingelheim Investigational Site Fukuoka, Kurume, Japan 1275.19.81504 Boehringer Ingelheim Investigational Site Fukushima, Koriyama, Japan 1275.19.81528 Boehringer Ingelheim Investigational Site Hiroshima, Hiroshima, Japan 1275.19.81501 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81502 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81503 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81532 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81505 Boehringer Ingelheim Investigational Site Ibaraki, Koga, Japan 1275.19.81533 Boehringer Ingelheim Investigational Site Ibaraki, Naka, Japan 1275.19.81516 Boehringer Ingelheim Investigational Site Kanagawa, Kawasaki, Japan 1275.19.81537 Boehringer Ingelheim Investigational Site Kanagawa, Sagamihara, Japan 1275.19.81538 Boehringer Ingelheim Investigational Site Kanagawa, Yokohama, Japan 1275.19.81520 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81521 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81539 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81517 Boehringer Ingelheim Investigational Site Nagano, Matsumoto, Japan 1275.19.81518 Boehringer Ingelheim Investigational Site Nagano, Matsumoto, Japan 1275.19.81525 Boehringer Ingelheim Investigational Site Osaka, Higashi-Osaka, Japan 1275.19.81523 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81526 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81527 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81540 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81522 Boehringer Ingelheim Investigational Site Osaka, Suita, Japan 1275.19.81524 Boehringer Ingelheim Investigational Site Osaka, Takatsuki, Japan 1275.19.81535 Boehringer Ingelheim Investigational Site Saitama, Hanno, Japan 1275.19.81506 Boehringer Ingelheim Investigational Site Saitama, Kawagoe, Japan 1275.19.81507 Boehringer Ingelheim Investigational Site Saitama, Saitama, Japan 1275.19.81534 Boehringer Ingelheim Investigational Site Saitama, Tokorozawa, Japan 1275.19.81509 Boehringer Ingelheim Investigational Site Tokyo, Chiyoda-ku, Japan 1275.19.81508 Boehringer Ingelheim Investigational Site Tokyo, Chuo-ku, Japan 1275.19.81512 Boehringer Ingelheim Investigational Site Tokyo, Chuo-ku, Japan 1275.19.81515 Boehringer Ingelheim Investigational Site Tokyo, Hachioji, Japan 1275.19.81511 Boehringer Ingelheim Investigational Site Tokyo, Koto-ku, Japan 1275.19.81513 Boehringer Ingelheim Investigational Site Tokyo, Meguro-ku, Japan 1275.19.81514 Boehringer Ingelheim Investigational Site Tokyo, Shinagawa-ku, Japan 1275.19.81510 Boehringer Ingelheim Investigational Site Tokyo, Shinjuku-ku, Japan Collapse << |
| NCT00954447 | - | - | Completed | - | - |
| NCT01826370 | - | - | Terminated | - | - |
| NCT02183480 | Healthy | Phase 1 | Completed | - | - |
| NCT02223026 | Healthy | Phase 1 | Completed | - | - |
| NCT01845077 | - | - | Completed | - | - |
| NCT01084005 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01216397 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1288.6.1 Boehringer Ingelheim Investigational Site Ingelheim, Germany Collapse << |
| NCT01084005 | - | - | Completed | - | - |
| NCT02183584 | Healthy | Phase 1 | Completed | - | - |
| NCT01216397 | - | - | Completed | - | - |
| NCT01826370 | - | - | Terminated | - | - |
| NCT02004366 | Type 2 Diabetes | Phase 4 | Completed | - | United States, Colorado ... more >> University of Colorado Denver, Colorado, United States, 80220 United States, Georgia Emory University Hospital Atlanta, Georgia, United States, 30322 Grady Memorial Hospital Atlanta, Georgia, United States United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Massachusetts Boston Medical Center Boston, Massachusetts, United States, 02118 Collapse << |
| NCT00935220 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... more >> 1218.55.0006 Boehringer Ingelheim Investigational Site Cypress, California, United States United States, Florida 1218.55.0008 Boehringer Ingelheim Investigational Site Deland, Florida, United States 1218.55.0004 Boehringer Ingelheim Investigational Site Miami, Florida, United States United States, Maryland 1218.55.0005 Boehringer Ingelheim Investigational Site Baltimore, Maryland, United States United States, New York 1218.55.0003 Boehringer Ingelheim Investigational Site New York, New York, United States United States, Texas 1218.55.0001 Boehringer Ingelheim Investigational Site Dallas, Texas, United States Collapse << |
| NCT02004366 | - | - | Completed | - | - |
| NCT00935220 | - | - | Completed | - | - |
| NCT02240680 | - | - | Completed | - | - |
| NCT01943019 | Schizophrenia | Phase 1 | Terminated(Inability to obtain... more >> patients) Collapse << | - | Malaysia ... more >> Pusat Perubatan Universiti Kebangsaan Malaysia Bandar Tun Razak, Kuala Lumpur, Malaysia, 56000 Collapse << |
| NCT03011177 | Type2 Diabetes Mellitus | Phase 4 | Recruiting | April 2019 | Korea, Republic of ... more >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: JY Park 82216887575 Collapse << |
| NCT02429232 | Osteoporosis ... more >>Diabetes Mellitus Collapse << | Phase 4 | Unknown | December 2017 | - |
| NCT03429543 | Diabetes Mellitus, Type 2 | Phase 3 | Recruiting | January 31, 2022 | - |
| NCT03667300 | Type2 Diabetes Mellitus ... more >> Albuminuria Renal Insufficiency Collapse << | Phase 2 | Enrolling by invitation | January 31, 2019 | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Collapse << |
| NCT02084082 | - | - | Completed | - | - |
| NCT02240680 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT02084056 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1288.11.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT02121509 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1288.10.1 Boehringer Ingelheim Investigational Site Ingelheim, Germany Collapse << |
| NCT02121509 | - | - | Completed | - | - |
| NCT01540487 | Healthy | Phase 1 | Completed | - | China ... more >> 1288.5.86001 Boehringer Ingelheim Investigational Site Beijing, China Collapse << |
| NCT02084056 | - | - | Completed | - | - |
| NCT01903070 | Diabetes Mellitus | Phase 4 | Completed | - | Germany ... more >> Profil Institut für Stoffwechselforschung GmbH Neuss, NRW, Germany, 41460 Collapse << |
| NCT02851745 | Diabetes Mellitus, Type 2 ... more >> Left Ventricular Systolic Dysfunction Collapse << | Phase 3 | Active, not recruiting | April 2019 | Italy ... more >> Azienda Ospedaliera Papa Giovanni Xxiii Bergamo, BG, Italy, 24127 P.O. Garibaldi-Nesima Catania, CT, Italy, 95122 Ospedale Casa Sollievo Della Sofferenza San Giovanni Rotondo, FG, Italy, 71013 Ospedale Villa Scassi Genova, GE, Italy, 16149 Iclas-Istituto Clinico Ligure Alta Spec. Rapallo, GE, Italy, 16035 Ospedale San Giuseppe Da Copertino Copertino, LE, Italy, 73043 Ospedale San Raffaele Milano, Lombardia, Italy, 20010 Policlinico G. Martino Messina, ME, Italy, 98124 Irccs Policlinico Multimedica Sesto San Giovanni, MI, Italy, 20099 A.O. Santa Croce e Carle Cuneo, Piemonte, Italy, 12100 Ospedale Sandro Pertini Roma, RM, Italy, 00157 Ospedale Maggiore Chieri, TO, Italy, 10023 Ospedale Mauriziano Torino, TO, Italy, 10128 Azienda Ospedaliera Santa Maria Terni, TR, Italy, 05100 Aas 1 Triestina Trieste, TS, Italy, 34148 Centro Cardiologico Monzino Milano, Italy, 20138 Aorn Osp. Dei Colli- Po Vincenzo Monaldi Napoli, Italy, 80131 Seconda Universita' Di Napoli Napoli, Italy, 80131 Casa di Cura Villa Bianca Trento, Italy, 38100 Collapse << |
| NCT01540487 | - | - | Completed | - | - |
| NCT02084082 | Healthy | Phase 1 | Completed | - | Germany ... more >> 1288.9.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse << |
| NCT03051243 | DM2 | Phase 3 | Not yet recruiting | November 1, 2019 | - |
| NCT02015299 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Netherlands ... more >> University Medical Center Groningen Groningen, Netherlands, 9700 RB Collapse << |
| NCT02857946 | Healthy | Phase 1 | Completed | - | Egypt ... more >> Genuine Research Center GRC Cairo, Egypt, 11757 Collapse << |
| NCT02061969 | Diabetes | Phase 4 | Completed | - | United States, Georgia ... more >> Crestvew Nursing Home Atlanta, Georgia, United States, 30315 Budd Terrace Nursing Home Atlanta, Georgia, United States, 30322 Wesley Woods Nursing Home Atlanta, Georgia, United States, 30322 VA Nursing Home Decatur, Georgia, United States, 30033 Collapse << |
| NCT02401880 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Germany ... more >> Profil Mainz GmbH & Co. KG Mainz, Germany, 55116 Profil Institut für Stoffwechselforschung GmbH Neuss, Germany, 41460 Collapse << |
| NCT02061969 | - | - | Completed | - | - |
| NCT03250052 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... more >> Kyungpook National University Hospital Seoul, Korea, Republic of Collapse << |
| NCT02212782 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... more >> Chonbuk National University Hospital Jeonju, Jeollabukdo, Korea, Republic of, 561-712 Collapse << |
| NCT02758171 | - | - | Completed | - | - |
| NCT03609294 | Hypertension ... more >>Diabetes Collapse << | Phase 1 | Recruiting | May 30, 2019 | Korea, Republic of ... more >> Seoul National University Hospital Recruiting Seoul, Dahak-ro, Korea, Republic of, 03080 Contact: Kyung-Sang Yu, MD, PhD Collapse << |
| NCT03004612 | Prediabetic State ... more >> Insulin Resistance Collapse << | Phase 4 | Active, not recruiting | August 2018 | Mexico ... more >> Universidad de Guanajuato León, Guanajuato, Mexico, 37670 Collapse << |
| NCT02350478 | Type 2 Diabetes ... more >> Coronary Artery Disease Collapse << | Phase 4 | Completed | - | Austria ... more >> Medical University of Graz, Department for Internal Medicine Graz, Austria, 8036 Collapse << |
| NCT01835678 | Type 2-diabetes | Phase 3 | Completed | - | Germany ... more >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Nuremberg, Germany, 90471 Collapse << |
| NCT02758171 | Healthy | Phase 1 | Completed | - | Germany ... more >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Collapse << |
| NCT02376075 | Arterial Hypertension ... more >> Albuminuria Collapse << | Phase 3 | Completed | - | Germany ... more >> Profil Mainz GmbH & Co. KG Mainz, Rhineland-Palatinate, Germany, 55116 Collapse << |
| NCT02815644 | Healthy | Phase 1 | Completed | - | Japan ... more >> SOUSEIKAI Sumida Hospital Tokyo, Sumida-ku, Japan, 133-0004 Collapse << |
| NCT02815644 | - | - | Completed | - | - |
| NCT03320031 | Type 2 Diabetes Mellitus ... more >> Peritoneal Dialysis Collapse << | Phase 4 | Recruiting | December 2019 | China, Guangdong ... more >> endocrinology department of the first affiliated hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Yanbing Li, MD,PhD 8602087334331 easd04lyb@126.com Principal Investigator: Yanbing Li, MD,PhD Collapse << |
| NCT02106104 | Type 2 Diabetes | Phase 4 | Completed | - | Netherlands ... more >> VU University Medical Center Amsterdam, Netherlands, 1081 HV Collapse << |
| NCT01617824 | Type 2 Diabetes ... more >> Chronic Renal Failure Collapse << | Phase 4 | Completed | - | Italy ... more >> University Hospital Diabetes Outpatient Clinic Padova, Italy, 35100 Collapse << |
| NCT02467478 | Type 2 Diabetes ... more >> Impaired Renal Function Collapse << | Phase 4 | Recruiting | December 2019 | United States, District of Col... more >>umbia The George Washington University Medical Faculty Associates Recruiting Washington, District of Columbia, United States, 20037 Contact: Fiona Dore, BS 202-741-2342 fdore@mfa.gwu.edu Collapse << |
| NCT02725502 | Type 1 Diabetes Mellitus | Not Applicable | Unknown | May 2016 | India ... more >> Department of Endocrinology, PGIMER Recruiting Chandigarh, India, 160012 Contact: Snajay Kr Bhadada, MD, DM bhadadask@rediffmail.com Contact: Soham Mukherjee, MD 9914743222 drsoham.mukherjee@gmail.com Principal Investigator: sanjay Kr Bhadada, MD, DM Collapse << |
| NCT02372630 | Type 2 Diabetes | Phase 4 | Active, not recruiting | May 2018 | United States, New York ... more >> ECMC Ambulatory Center, 3rd Floor Buffalo, New York, United States, 14215 Collapse << |
| NCT03338803 | - | - | Completed | - | United States, Minnesota ... more >> Optum Eden Prairie, Minnesota, United States, 55344 Collapse << |
| NCT02077309 | Diabetes Mellitus Type 2 (T2DM... more >>) Vascular Inflammation Plaque Morphology Collapse << | Phase 3 | Terminated(bad recruitment of ... more >>suitable participants, just 4 patients in one year) Collapse << | - | Germany ... more >> Department of Internal Medicine I, University Hospital Aachen, Germany, 52074 Netherlands Cardiovascular Research Institute Maastricht (CARIM) Maastricht, Netherlands, 6229 Collapse << |
| NCT02442817 | Schizophrenia | Phase 4 | Unknown | May 2017 | United States, Nevada ... more >> University of Nevada School of Medicine Recruiting Reno, Nevada, United States, 89503 Contact: Brian Kirkpatrick, MD 775-682-8449 bkirkpatrick@medicine.nevada.edu Principal Investigator: Brian Kirkpatrick, MD Collapse << |
| NCT02280174 | Type 2 Diabetes | Phase 4 | Unknown | October 2016 | Argentina ... more >> National University of Formosa Recruiting Formosa, Argentina, 3600 Contact: Juan Pa Nogueira, MD/PhD 00543704425447 nogueirajuanpatricio@gmail.com Collapse << |
| NCT02097342 | Type 2 Diabetes Mellitus ... more >> Insulin Sensitivity/Resistance Collapse << | Phase 4 | Unknown | January 2015 | India ... more >> Postgraduate Institute of Medical Education & Research Recruiting Chandigarh, India, 160012 Contact: Anil Bhansali, MD DM anilbhansaliendocrine@gmail.com Collapse << |
| NCT02752113 | Diabetes Mellitus Type 2 | Phase 3 | Recruiting | January 2019 | Germany ... more >> Clinical Research Center, Dept of Nephrology and Hypertenison, University of Erlangen/Nürnberg Recruiting Erlangen, Bavaria, Germany, 91054 Contact: Christian Ott, MD +49-9131-85 ext 36245 christian.ott@uk-erlangen.de Contact: Roland Schmieder, Prof. MD +49 9131 85 ext 36245 roland.schmieder@uk-erlangen.de Principal Investigator: Roland Schmieder, Prof. MD Sub-Investigator: Christian Ott, MD Collapse << |
| 靶点 | Description | IC50 |
|---|---|---|
| DPP4 | IC50:1nM |
