生物活性

• 描述Rosmarinic acid is specific inhibitor of ε-Pol. The rosmarinic acid treatment significantly decreased extracellular HBV DNA with rough estimation of EC50 of 30 μM^[3]. in vitro, rosmarinic acid significantly affected root morphology causing an inhibition of both total and primary root length with 71 μM and 175 μM ED50 values, respectively^[4]. in vivo, rosmarinic acid at a dose of 50 mg/kg induced a decrease in the total cholesterol and triglyceride concentrations^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03365648	Allergic Rhinoconjunctivitis	Not Applicable	Completed	-	Italy ... more >> Fondazione IRCCS Policlinico San Matteo Pavia, (pv), Italy, 27100 Ospedale regionale San Salvatore - ASL 1 Avezzano Sulmona L'Aquila L'Aquila, AQ, Italy, 67100 A.O.U. Consorziale "Policlinico Giovanni XXIII" Bari, BA, Italy, 70126 A.O.U. Consorziale "Policlinico-Giovanni XXIII" Bari, BA, Italy, 70126 A.O.U. Policlinico Vittorio Emanuele Catania, CT, Italy, 95123 Istituto Giannina Gaslini Genova, GE, Italy, 16132 P.O. San Giovanni di Dio - ASP di Crotone Crotone, KR, Italy, 88900 A.O.U. Policlinico "G. Martino" Messina, ME, Italy, 98124 P.O. G. Salvini di Garbagnate Milanese - ASST Rhodense Garbagnate Milanese, MI, Italy, 20042 Ospedale Civile di Legnano - ASST Ovest Milanese Legnano, MI, Italy, 20162 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, MI, Italy, 20122 Ospedale San Carlo Borromeo - ASST Azienda Socio Sanitaria Territoriale Santi Paolo E Carlo Milano, MI, Italy, 20157 Ospedale Città di Sesto San Giovanni - ASST Nord Milano Sesto San Giovanni, MI, Italy, 20099 Ospedale di Polistena "Santa Maria degli Ungheresi" - ASP di Reggio Calabria Polistena, RC, Italy, 89024 A.O.U. Policlinico Umberto I Roma, RM, Italy, 00161 P.O. di Busto Arsizio - ASST Valle Olona Busto Arsizio, VA, Italy, 21051 Az. Osp. Univ. dell'Università degli Studi della Campania "Luigi Vanvitelli" Napoli, Italy, 80138 Collapse <<
  NCT03382067	Test Anxiety	Not Applicable	Completed	-	Switzerland ... more >> University of Basel, Division of Cognitive Neuroscience Basel, Switzerland, 4055 Collapse <<
  NCT01380015	Osteoarthritis of the Knee	Phase 4	Completed	-	Canada, Ontario ... more >> University of Guelph Guelph, Ontario, Canada, N1G 2W1 Human Nutraceutical Research Unit, University of Guelph Guelph, Ontario, Canada, N1G2W1 Collapse <<

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• 参考文献

• [1] Andrade JM, Dos Santos Passos C, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.

  [2] Fernando PM, Piao MJ, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84.

  [3] Tsukamoto Y, Ikeda S, Uwai K, et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLoS One. 2018;13(5):e0197664. Published 2018 May 21.

  [4] Araniti F, Costas-Gil A, Cabeiras-Freijanes L, et al. Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction. PLoS One. 2018;13(12):e0208802. Published 2018 Dec 26.

  [5] Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats. Nutrients. 2019;11(2):267. Published 2019 Jan 25.

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