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CAS No.: 56287-61-7

(S)-2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride Catalog No. CSN27295

Synonyms: (S)-2-[(2-Ethoxyphenoxy)methyl]morpholine Hydrochloride;(S)-2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine Hydrochloride

(S)-Viloxazine Hydrochloride is the S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.

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技术信息

生物活性

描述(S)-Viloxazine Hydrochloride is S(+)-isomers of the atypical antidepressant viloxazin (Viloxazine) can as a norepinephrine reuptake inhibitor (NRI). n vitro, viloxazine demonstrated antagonistic activity at 5-HT2B and agonistic activity at 5-HT2C receptors, along with predicted high receptor occupancy at clinical doses. In vivo, viloxazine increased extracellular 5-HT levels in the prefrontal cortex (PFC), a brain area implicated in ADHD (attention deficit/hyperactivity disorder). Viloxazine also exhibited moderate inhibitory effects on the norepinephrine transporter (NET) in vitro and in vivo, and elicited moderate activity at noradrenergic and dopaminergic systems^[2]. The AMDP-evaluation suggests that viloxazin has a somewhat more marked and more rapid effect on symptoms of retardation, whereas amitriptyline acts predominantly on depressive mood, disturbances of sleep and vital feelings. The viloxazine blood levels showed a remarkably low inter- and intraindividual variance^[3]. Fourteen consecutive daily injections of either the racemate or the S-isomer (2, 5 and 10 mg kg-1 i.p.) significantly improved the acquisition of avoidance behaviour. Racemic viloxazine caused a concentration-dependent (10(-5)-10(-3 M) release of 5-MT without affecting any significant change in the release of either catecholamine^[4].
参考文献

[1] Matthews PRL, Horder J, Pearce M. Selective noradrenaline reuptake inhibitors for schizophrenia. Cochrane Database Syst Rev. 2018;1(1):CD010219.
[2] Yu C, Garcia-Olivares J, Candler S, Schwabe S, Maletic V. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300
[3] Müller-Oerlinghausen B, Rüther E. Clinical profile and serum concentration of viloxazine as compared to amitriptyline. Pharmakopsychiatr Neuropsychopharmakol. 1979 Jul;12(4):321-37
[4] Greenwood DT, Kemp JD, Middlemiss DN. Stereospecificity of behavioural effects of viloxazine in bulbectomized rats does not correlate with its 5-HT-releasing action in vitro. J Pharm Pharmacol. 1982 Jan;34(1):38-41

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6529 mL
- 18.2645 mL
- 36.5289 mL
- 5 mM
- 0.7306 mL
- 3.6529 mL
- 7.3058 mL
- 10 mM
- 0.3653 mL
- 1.8264 mL
- 3.6529 mL

技术信息

CAS号	56287-61-7	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C13H20ClNO3	运输	蓝冰
分子量	273.76	别名	(S)-2-[(2-Ethoxyphenoxy)methyl]morpholine Hydrochloride;(S)-2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine Hydrochloride

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(S)-2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride Catalog No. CSN27295

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