|(S)-2-((2S,3S,4S)-2-氨基-5-(氨基甲酰氧基)-3,4-二羟基戊酰胺)-2-((2R,3S,4R,5R)-3,4-二羟基-5-(5-(羟甲基)-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-2-基)乙酸|CsnPharm

CAS No.: 19396-06-6

Synonyms: Polyoxin B

Polyoxin B is a competitive inhibitor of chitin synthetase.

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400-920-2911

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描述Polyoxin B acts as an competitive inhibitor of chitin synthetase, which is concerned in the synthesis of cell-wall chitin of A. kikuchiana. The polyoxin-resistance of this fungus is caused by a lowered penetration of the antibiotic through the cell membrane into the enzyme site. In vitro，polyoxin B, at a concentration of 10 μM, inhibited more than 50% of the incorporation of glucosamine-14C into cell-wall chitin in washed mycelia of the polyoxin-sensitive strains and at the same time resulted in an unusually increased accumulation of UDP-N-acetylglucosamine-14C, which is a precursor of chitin biosynthesis^[3].
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技术信息

CAS号	19396-06-6	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H25N5O13	运输	蓝冰
分子量	507.41	别名	Polyoxin B

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