生物活性

• 描述S(+)-ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02343315	Chronic Low Back Pain	Not Applicable	Not yet recruiting	December 2020	-
  NCT03626389	-	-	Recruiting	June 30, 2021	Norway ... more >> Approx 100 physiotherapists in Norway Recruiting Oslo, Norway Contact: Hilde S Robinson, PhD       h.s.robinson@medisin.uio.no    Principal Investigator: Hilde S Robinson, PhD          Sub-Investigator: Nina K Vøllestad, PhD          Sub-Investigator: Wenche S Bjorbækmo, PhD          Physiotherapists in Trondheim Recruiting Trondheim, Norway Contact: Ottar Vasseljen, PhD       ottar.vasseljen@ntnu.no    Principal Investigator: Ottar Vasseljen, PhD          Sub-Investigator: Kari AI Evensen, PhD          Sub-Investigator: Ingebrigt Meisingset, PhD          Sub-Investigator: Astrid Woodhouse, PhD Collapse <<
  NCT02884219	Patent Ductus Arteriosus	Not Applicable	Recruiting	June 2020	Belgium ... more >> University Hospital Antwerp Not yet recruiting Antwerp, Belgium Contact: David van Laere, MD PhD          Hôpital Erasme - Clinique Universitaires de Bruxelles Not yet recruiting Brussels, Belgium Contact: Bart van Overmeire, Prof          University Hospital Brussels Not yet recruiting Brussels, Belgium Contact: Filip Cools, Prof          Netherlands Academic Medical Center Recruiting Amsterdam, Netherlands Contact: Wes Onland, MD PhD          Free University Amsterdam Not yet recruiting Amsterdam, Netherlands Contact: Harry Lafeber, Prof.dr.          University Medical Center Groningen Not yet recruiting Groningen, Netherlands Contact: Elisabeth Kooi, MD PhD          Leiden University Medical Center Not yet recruiting Leiden, Netherlands Contact: Remco Visser, MD PhD          Maatricht University Medical Center Not yet recruiting Maastricht, Netherlands Contact: Eduardo Villamor, MD PhD          Radboudumc Amalia Children's Hospital Recruiting Nijmegen, Netherlands Contact: Willem de Boode, MD PhD          Erasmus Medical Center Rotterdam Not yet recruiting Rotterdam, Netherlands Contact: Johan de Klerk, MD PhD          Wilhelmina Children's Hospital/UMCU Not yet recruiting Utrecht, Netherlands Contact: Daniël Vijlbrief, MD PhD          Maxima Medical Center Not yet recruiting Veldhoven, Netherlands Contact: Koen Dijkman, MD PhD          Isala Kliniek Zwolle Not yet recruiting Zwolle, Netherlands Contact: S. de Tollenaer, MD PhD Collapse <<

• 更多
• 参考文献

• [1] Kato M, Nishida S, et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 2001 Dec;53(12):1679-85.

  [2] Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993 Mar 25;268(9):6610-4.