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CAS No.: 84057-95-4

罗哌卡因 Catalog No. CSN27570

Synonyms: Narop;Noropine;Ropivacaina

Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.

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描述Ropivacaine is a long-acting local anesthetic agent that can cause reversible inhibition of sodium ion influx in nerve fibers, thereby blocking impulse conduction. Ropivacaine at concentrations of 3.75 and 1.88mg/mL inhibited platelet aggregation in plasma (0.375% and 0.188%, respectively). It exhibits antibacterial activity in vitro, inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa^[5]. The exposure of PC-12 cells with ropivacaine (10 - 200μg/mL) inhibited neurite outgrowth in a dose-dependent manner^[6]. Ropivacaine (0.2%, 400μL) and liposomal bupivacaine (1.3%, 400μL) blocked sensory processing in male C57BL/6 mice without affecting motor behavior. Ropivacaine treatment also prevented mechanical allodynia in mice during repeated social defeat without affecting behavioral or immune responses to stress^[7].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6443 mL
- 18.2215 mL
- 36.4430 mL
- 5 mM
- 0.7289 mL
- 3.6443 mL
- 7.2886 mL
- 10 mM
- 0.3644 mL
- 1.8222 mL
- 3.6443 mL

技术信息

CAS号	84057-95-4	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H26N2O	运输	蓝冰
分子量	274.40	别名	Narop;Noropine;Ropivacaina;Ropivacainum;LEA-103;罗哌卡因

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