|(S)-2-氨基-3-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)丙酸|CsnPharm

CAS No.: 21416-43-3

Synonyms: (-)-Willardiine;尿嘧啶基丙氨酸

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 μM.

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400-920-2911

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描述(S) -Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. Willardiines produce strikingly different degrees of desensitization: at saturating doses the equilibrium response to the weakly desensitizing agonist (S)-5-iodowillardiine was similar in amplitude to the response to kainate and 10 times larger than the response to the strongly desensitizing agonist (S)-willardiine^[3]. In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists^[4]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50%. Ca2+ inhibition of the willardiine-induced response is concentration dependent^[5].
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CAS号	21416-43-3	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C7H9N3O4	运输	蓝冰
分子量	199.16	别名	(-)-Willardiine;尿嘧啶基丙氨酸

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