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CAS No.: 64439-81-2

(±)-10-Hydroxycamptothecin/10-羟基喜树碱 Catalog No. CSN20799

Synonyms: (±)-10-HCPT;10-HCPT;10-羟基喜树碱

(±)-10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate.

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描述10-Hydroxycamptothecin (HCPT) is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity. It can be isolated from camptotheca acuminate. Gel electrophoresis found that HCPT had a selectively inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on the other kinds of histones. In vivo, HCPT also exhibited a suppressive effect on histone H1 and H3 phosphorylation^[1]. After treatment with HCPT at differentiation-inducing concentrations 5-20 mg/L for 6 d, Hep G2 cells were mainly arrested at G2/M phase and the PCNA expression rate was lower than that of control cells. When Hep G2 cells grew in a medium containing HCPT 5 mg/L for 6 d, the p53 expression level markedly increased in comparison with the control cells. The telomerase activity did not change in Hep G2 cells treated with HCPT 5-20 mg/L for 8 d^[2]. HCPT exhibited adverse effects on mouse oocyte maturation and quality, and MT (Melatonin) administration alleviated the negative influence of HCPT^[3].
参考文献

[1] Ling YH, Xu B. Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin, DNA topoisomerase I inhibitor, in murine ascites hepatoma cells. Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):546-50
[2] Zhang XW, Jiang JF, Xu B. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21(4):364-8
[3] Wang L, Zhang J, Zhao C, Jia Z, Feng X. Melatonin Reverses 10-Hydroxycamptothecin-Induced Apoptosis and Autophagy in Mouse Oocyte. Reprod Sci. 2021 Jul;28(7):1839-1849

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7446 mL
- 13.7231 mL
- 27.4461 mL
- 5 mM
- 0.5489 mL
- 2.7446 mL
- 5.4892 mL
- 10 mM
- 0.2745 mL
- 1.3723 mL
- 2.7446 mL

技术信息

CAS号

64439-81-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H16N2O5

运输

蓝冰

分子量

364.35

别名

(±)-10-HCPT;10-HCPT;10-羟基喜树碱

溶解度

DMSO	70.0 mg/mL (192.1 mM) warming
Water	insoluble

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(±)-10-Hydroxycamptothecin/10-羟基喜树碱 Catalog No. CSN20799

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